P30 Pilot Funding
ROCSTARR Request for Proposals: Pilot Studies
As part of the Pilot & Feasibility Studies Program in NIAMS, P30 AR069655, the Rochester Resource-based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) is now requesting applications from Early Career Investigators for funding of pilot projects. Investigator-initiated pilot studies for non-tenured, full-time faculty Principal Investigators are eligible to apply for research funding relevant to Musculoskeletal Diseases ($25,000 maximum for one year).
All principal investigators of proposals must be faculty at the University of Rochester. Co-investigators may be from other institutions. Funding cannot be used to support faculty salary. Trainee salary support is permitted, but must be justified in the proposal. Renewal of funding of investigator-initiated pilots for a second year may be possible under special circumstances where considered justified, and revised applications from prior proposals submitted for P30 or CTSI pilot funding may be submitted. Concurrent funding of more than a single pilot award to an investigator from the ROCSTARR is not permitted.
The pilot grant program is intended to provide seed funding to facilitate new research and future funding. Multidisciplinary research is strongly encouraged, as well as translational and clinical research that moves new discoveries along the translational continuum to humans and the community. Clinical and community-based research, education and training, practice-based research, and health services research proposals are also encouraged.
Proposal Submission
A face page application form and investigator’s proposal (in a modified NIH format with a six page maximum, 11-point font minimum) and budget form with a budget justification should be submitted electronically by email to Martha Young, phone: 585-275-1397.
Deadline
ROCSTARR Proposals must be received by Monday, September 16, 2024, using the Request for Proposals: Pilot Studies Form. Email the completed form to Martha Young.
Applicants will be notified of awards by December 18, 2024, which will be initiated on January 1, 2025. The funding must be expended by December 31, 2025.
Note: All animal and human subject protocols must be approved prior to the start date. No funds will be released until these approvals have been documented. If approvals are not received prior to the start date, then the applicant will not receive the award.
Please see the full announcement for more details.
ROCSTARR (formerly URCCMBM) Pilot Awardees
| Date | Awardee | Title |
|---|---|---|
| 2023-2024 | Calvin Cole, PhD | Insulin-like Growth Factor Binding Protein-3 as a Treatment Target for Pancreatic Cancer and Related Skeletal Muscle Wasting |
| 2023-2024 | Jennifer Jonason, PhD | Examining the Consequences of Chronic Pro-inflammatory Signaling in Chondrocytes on Joint Pain and Innervation |
| 2023-2024 | Samuel Mackenzie, PhD | Suppressor tRNA-Mediated Dystrophin Restoration in Nonsense-Mediated Duchenne Muscular Dystrophy |
| 2023-2024 | Chia-Lung Wu, PhD | The Role of PRDM16 and KDM3B in Cartilage Development and Homeostasis |
| 2022-2023 | Ram Haddas, PhD | Feasibility of Telehealth Functional Assessments Using Wearables to Improve the Treatment of Low Back Pain Among Suburban and Underrepresented Minority Poplulations: A Pilot Study |
| 2022-2023 | Xi Lin, PhD | EGR1 as a Novel Transcription Factor that Contributes to Age-Related OA by Promoting the Dedifferentiation of Synovial Fibroblasts |
| 2022-2023 | Gowrishankar Muthukrishnan, PhD | Examining IL-17/IL-17R Axis in IL-27-Mediated Neutrophilic Responses During Staphylococcus Aureus Osteomyelitis |
| 2022-2023 | Shu-Chi (Allison) Yeh, PhD | The Role of Bone Remodeling in Regulating Hematopoietic Aging |
| 2021-2022 | Jeevisha Bajaj, PhD |
Role of Taurine from Osteolineage Cells in Osteogenic Differentiation and Myeloid Disease Progression
|
| 2021-2022 | Chike Cao, PhD |
Interplay between increased Ca2+ signaling through CaV1.2 and canonical BMP pathway
during bone development and Achilles tendon heterotopic ossification |
| 2021-2022 | Ananta Paine, PhD /
Maria de la Luz Garcia-Hernandez, PhD
|
Generation of a Conditional Knock-Out Reporter Knock-in Mouse Model to Define Cell-Specific Functions of Thy1
|
| 2020-2021 | John Daiss, PhD |
Essential Steps for Making MENSA-based Immunoassays Simpler for Research Laboratories and Hospitals
|
| 2020-2021 | Thomas Fountaine, MD | Functional Role of Human Bone Marrow Mesenchymal Stem and Progenitor Cell Subsets in Myelodysplastic Syndrome |
| 2020-2021 | Patrick Murphy, PhD | Epigenetic Regulation of Neural Crest Cells Development Controls Zebrafish Cartilage Formation |
| 2020-2021 | Katherine Rizzone, MD | Improving Long-Term Activity Levels and Health Outcomes in At-Risk, Underrepresented Adolescent Females Through Implementation of a Teacher-Student Physical Activity Program |
| 2019-2020 | Jonathan Leckenby, MD, PhD | Development of a Murine Model to Investigate Scar Formation within the Regenerating Nervous System |
| 2019-2020 | Whasil Lee, PhD | Targeting Mechanosensitive Ion Channels for ACL-Injury Associated Osteoarthritis: Evaluation in a Mouse Model |
| 2019-2020 | Gowrishankar Muthukrishnan, PhD | Defining the Role of IL-27/IL-27R Signaling in Septic Death following Staphylococcus aureus Implant-Associated Osteomyelitis |
| 2019-2020 | Homaira Rahimi, MD, MTR | Validation of Hand NIR-ICG Imaging to Evaluate Lymphatic Flow in Health and Arthritic Flare |
| 2018-2019 | Calvin Cole, PhD | IL-12 Treatment Attenuation of Skeletal Muscle Loss in Murine Model of Pancreatic Cancer |
| 2018-2019 | Constantinos Ketonis, MD, PhD | Establishment of the Murine Model of Pyogenic Flexor Tenosynovitis and Investigation of Novel Treatment Strategies |
| 2018-2019 | Jennifer Jonason, PhD | Inflammation-Mediated Mineralization of the Meniscus in OA Pathogenesis |
| 2018-2019 | Yi (Stanley) Zhang, PhD | Investigation into the Mechanism of Radioulnar Synotosis |
| 2017-2018 | Mark Buckley, PhD | The Influence of Chondrocyte Mechano-Protective Adaptation on the Progression of Osteoarthritis |
| 2017-2018 | Roman Eliseev, MD, PhD | Generation of a Novel Transgenic Mouse to Study the Role of Mitochondrial Dysfunction in the Pathogenesis of Osteoarthritis |
| 2017-2018 | Jennifer Jonason, PhD | Role of CCL20/CCR6 Chemokine Axis in the Development of Post-Traumatic Osteoarthritis |
| 2017-2018 | Caroline Thirukumaran, PhD | Big Data Methods for Surveillance of Post-Operative Complications in Orthopaedics |
| 2016-2017 | John Elfar, MD | 4AP To Prevent Muscle Atrophy after Peripheral Nerve Injury |
| 2016-2017 | Jennifer Jonason, PhD | The Role of RUNX2 in the Progression of Post-Traumatic Osteoarthritis |
| 2016-2017 | Catherine Kuo, PhD | Axial and Limb Tendon Progenitor Cell Baseline and FGF4-Induced Differences |
| 2016-2017 | Hengwei Zhang, PhD | Proteasome inhibition enhanced bone fracture healing through PDGFRb signaling |
| 2015-2016 | Reyad Elbarbary, PhD | Regulation of Adipogenesis by Tudor-SN-mediated miRNA Decay: Implications in Obesity-impaired Fracture Healing |
| 2015-2016 | Roman Eliseev, MD, PhD | Effect of cyclophilin D knock-out on bone loss after hormone depletion |
| 2015-2016 | Benjamin Frisch, PhD | The role of CCL3 in Leukemia-induced osteolineage Dysfunction |
| 2015-2016 | David Weber, MD | Assessment of Calcium Metabolism in Adolescents with Type 1 Diabetes Using a Dual Stale Calcium Isotopes Method |
| 2014-2015 | Mark Buckley, PhD | Defining the Role of Mechanical Compression in Insertional Achilles Tendinopathy |
| 2014-2015 | John Daiss, PhD | Diagnosis and Monitoring of Ongoing Staphylococcus aureus Infections Using Circulating Cell-Free Bacterial DNA and Circulating Antibody-Secreting Cells |
| 2014-2015 | Tzong-jen Sheu, PhD | Cobalt Ion Release Alters Skeletal Metabolism: A Mechanism for Bone Loss in Metal-on-Metal Orthopaedic Implants |
| 2014-2015 | Hengwei Zhang, MD | Proteasome inhibitor VELCADE enhances bone fracture healing by inhibiting ubiquitination and degradation of osteoblast positive regulators in callus |
| 2013-2014 | Yufeng Dong, MD, PhD | Clinical grade expansion of functional Mesenchymal stem cells from human bone marrow in cGMP facility |
| 2013-2014 | Zhenqiang Yao, MD | TRAF3 levels in Blood Monocytes in Rheumatoid Arthritis |
| 2013-2014 | Luiz Meirelles, DDS, PhD | Novel free radicals therapeutic device to treat implant associated osteomyelitis |
| 2013-2014 | Wakenda Tyler, MD, MPH | MicroRNA impact on Angiogenesis & Tumor Growth in Metastatic Renal Cancer to Bone |
| 2012-2013 | John Daiss, PhD | Targeted Lytic Agents for the Prevention and Elimination of Staphylococcus aureus Infections |
| 2012-2013 | Yufeng Dong, MD | Assessment of skeletal stromal cell sheets for repair of critical segmented bone defects |
| 2012-2013 | Roman Eliseev, MD, PhD | Targeting metabolic reprogramming in osteosarcoma |
| 2012-2013 | Yi Zhang, PhD | MEm1/m1 mouse as a potential model for Scheuermann disease |
| 2012-2013 | Michael Maloney, MD | Correlation of vascular and anatomical response with structural and clinical outcome: a pilot study in patients who have undergone rotator cuff repair surgery |
| 2011-2012 | Stephen Kates, MD | Evaluation of Anti-Autolysin titers against S. aureus in Patients with Infected Total Joint Replacements and Development to a Clinical Serum ELISA to Assess the Probability of Reinfection |
| 2011-2012 | Jennifer Jonason, PhD | Examination of the Effects of Chondrocyte-specific Runx2 Overexpression on Endochondral Bone Formation and Postnatal Articular Cartilage Homeostasis |
| 2011-2012 | Chao Xie, MD | PTH Effects on Intravenously Delivered hMSC during Skeletal Repair |
| 2011-2012 | Zhenqiang Yao, MD | The Role of NF-kB RelB in Fracture Healing |
Louis A. Goldstein and Mildred M. Goldstein Orthopaedic Research Award
Each year faculty members are encouraged to apply for The Goldstein Award. This endowment gifted by Louis A. Goldstein and Mildred M. Goldstein is for funding of clinical Orthopaedic research. This gift enables faculty to generate pilot data from which they can apply for additional funding.
Goldstein Awardees
| Date | Awardee | Title |
|---|---|---|
| 2020 | Benjamin Ricciardi, MD | What is the effect on patient travel burden of centralizing revision total hip and total knee arthroplasty care in New York State? |
| 2020 | Susan Nelson, MD | Perioperative Integrative Medicine to Address Stressors Amongst Adolescents Undergoing Orthopaedic Surgery: Assessment and Feasibility of Pilot Clinical Program |
| 2020 | Thomas Myers, MD | Quantifying Surgeon Work During Primary & Revision Total Joint Arthroplasty |
| 2020 | Addisu Mesfin, MD | Anabolic and Catabolic Marker Expression in Human Intervertebral Disc Specimen |
| 2020 | Judith Baumhauer, MD | Validity of a Self-Administered “Get Up and Go” Test and PROMIS Physical Function Assessment to Identify Elderly Patients at Risk to Fall |
| 2019 | Ilya Voloshin, MD | Should Internal Rotation be Restricted after Reverse Total Shoulder Arthroplasty? |
| 2019 | Irvin Oh, MD | Biomechanical Changes of Hindfoot Motion Associated with Talonavicular Arthrodesis |
| 2019 | Thomas Myers, MD | Can Machine Learning Using Large Scale Administrative Data Predict 90-day Complications and Readmissions After Elective Total Hip and Total Knee Replacement at University of Rochester? |
| 2019 | Warren Hammert, DDS, MD | Artificial Intelligence/Machine Learning Analysis of Plain Hand X-rays for Early Osteoporosis Screening |
| 2018 | Ilya Voloshin, MD | Mid-Term Outcomes of Uncemented Second Generation Trabecular MetalTM Glenoid Components in Total Shoulder Arthroplasty |
| 2018 | Constantinos Ketonis, MD | Non-invasive assessment of the ulnar nerve around the elbow and diagnosis of cubital tunnel using machine learning |
| 2018 | Brian Giordano, MD | Gene expression in Femoroacetabular Impingement and Osteoarthritis: Evaluating Markers of Inflammation and Bone Metabolism |
| 2017 | Irvin Oh, MD | Instability in Cadaveric Flatfoot Model |
| 2016 | John Ginnetti, MD | Biomechanical Advantage of Acetabular Screws in revision Total Hip Arthroplasty with Bone Loss |
| 2016 | Emily Carmody, MD | Establishing Therapeutic molecular Targets in Oncology Synovial Sarcoma |
| 2015 | John Elfar, MD | Erythropoietin for Compression Neuropathy: Preclinical Efficacy and Cellular Site of Action |
| 2015 | Irvin Oh, MD | Clinical Applicability of Circulating Antibody-Secreting Cells and Microbiome Analysis for Assessments of Treatment Response and Prognosis of Active Staphylococcus aureus Infections in Diabetic Foot Ulcer |
| 2014 | Addisu Mesfin, MD | Reducing Dysphagia Following Anterior Cervical Spine Surgery: A prospective Randomized Double-Blind Placebo Trial |
| 2014 | Brian D. Gioardno, MD | The influence of periarticular hip dysfunction on the progression of osteoarthritis |
| 2013 | Gregg Nicandri MD and Stephen Kates, MD | The Development, Implementation and Validation of an Orthopaedic Surgical Skills Curriculum: A Pilot Study Focusing on the Treatment of Hip Fractures with a Dynamic Hop Screw or Trochanteric Femoral Nail and the Treatment of Meniscal Tears of the Knee with Arthroscopic Partial Menisectomy |
| 2012 | Benedict DiGiovanni, MD and Deborah A. Nawoczenski, PT, PhD | Biomechanical and Muscle morphological Biomarkers of Foot Function Following Gastrocnemius Recession for Achilles Tendinopathy |
| 2011 | John Elfar, MD | Parathyroid Hormone in Rotator Cuff Tears |