Pediatrics / A. Rahman Lab / Publications Publications Millar MWNajar RASlavin SAShadab MTahir IMahamed ZLin XAbe JIWright TWDean DAFazal FRahman A MTOR maintains endothelial cell integrity to limit lung vascular injury.; The Journal of biological chemistry. 2024 Nov 05. Lin XBai HBarravecchia MNorman RSchiralli Lester GMKottmann RMLeonard ARahman AYoung JLDean DA Occludin Is Essential to Maintain Normal Alveolar Barrier Integrity and Its Protective Role During ARDS Progression.; International journal of molecular sciences; Vol 25(21). 2024 Oct 29. Vandewouw MMNorris-Brilliant ARahman AAssimopoulos SMorton SUKushki ACunningham SKing EGoldmuntz EMiller TAThomas NHAdams HRCleveland JCnota JFEllen Grant PGoldberg CSHuang HLi JSMcQuillen PPorter GARoberts AERussell MWSeidman CETivarus MEChung WKHagler DJNewburger JWPanigrahy ALerch JPGelb BDAnagnostou E Identifying novel data-driven subgroups in congenital heart disease using multi-modal measures of brain structure.; NeuroImage; Vol 297, pp. 120721. 2024 Jul 04. Shadab MSlavin SAMahamed ZMillar MWNajar RALeonard APietropaoli ADean DAFazal FRahman A Spleen Tyrosine Kinase phosphorylates VE-cadherin to cause endothelial barrier disruption in acute lung injury.; The Journal of biological chemistry; Vol 299(12), pp. 105408. 2023 Oct 28. Jagrosse MLBaliga UKJones CWRussell JJGarcía CINajar RARahman ADean DANilsson BL Impact of Peptide Sequence on Functional siRNA Delivery and Gene Knockdown with Cyclic Amphipathic Peptide Delivery Agents.; Molecular pharmaceutics. 2023 Jan 14. Schartz DAIsmail RFRahman AABender MTWestesson PLMesfin AKessler A Management of postoperative cervical pseudomeningocele with percutaneous aspiration and epidural blood patch.; Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences. 2022 Jul 11. Millar MWFazal FRahman A Therapeutic Targeting of NF-κB in Acute Lung Injury: A Double-Edged Sword.; Cells; Vol 11(20). 2022 Jan 21. McRae HLMillar MWSlavin SABlumberg NRahman ARefaai MA Essential Role of Rho-Associated Kinase in ABO Immune Complex-Mediated Endothelial Barrier Disruption.; Biomedicines; Vol 9(12). 2021 Dec 07. Hsu CGFazal FRahman ABerk BCYan C Phosphodiesterase 10A Is a Key Mediator of Lung Inflammation.; Journal of immunology (Baltimore, Md. : 1950). 2021 Jun 11. Shadab MMillar MWSlavin SALeonard AFazal FRahman A Autophagy protein ATG7 is a critical regulator of endothelial cell inflammation and permeability.; Scientific reports; Vol 10(1). 2020 Aug 13. Leonard ASu PYYule DIRahman AFazal F Critical Role of Mortalin/GRP75 In Endothelial Cell Dysfunction Associated With Acute Lung Injury.; Shock (Augusta, Ga.). 2019 Sep 04. Xu SXu YLiu PZhang SLiu HSlavin SKumar SKoroleva MLuo JWu XRahman APelisek JJo HSi SMiller CLJin ZG The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis.; European heart journal; Vol 40(29). 2019 Aug 01. Jagrosse MLDean DARahman ANilsson BL RNAi therapeutic strategies for acute respiratory distress syndrome.; Translational research : the journal of laboratory and clinical medicine. 2019 Jul 27. Leonard AMillar MWSlavin SABijli KMDionisio Santos DADean DAFazal FRahman A Critical role of autophagy regulator Beclin1 in endothelial cell inflammation and barrier disruption.; Cellular signalling. 2019 May 01. Leonard AGrose VPaton AWPaton JCYule DIRahman AFazal F Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury.; Scientific reports; Vol 9(1). 2019 Feb 14. Lyu QXu SLyu YChoi MChristie CKSlivano OJRahman AJin ZGLong XXu YMiano JM SENCR stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4.; Proceedings of the National Academy of Sciences of the United States of America; Vol 116(2). 2019 Jan 08. Leonard ARahman AFazal F Importins α and β signaling mediates endothelial cell inflammation and barrier disruption.; Cellular signalling. 2018 Jan 10. Slavin SALeonard AGrose VFazal FRahman A Autophagy Inhibitor 3-Methyladenine Protects against Endothelial Cell Barrier Dysfunction in Acute Lung Injury.; American journal of physiology. Lung cellular and molecular physiology. 2017 Oct 26. Angara SSyed MDas PJanér CPryhuber GRahman AAndersson SHomer RJBhandari V Inhibition of RPTOR Prevents Hyperoxia-induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice.; American journal of respiratory cell and molecular biology. 2016 Jul 2. Bijli KMFazal FSlavin SALeonard AGrose VAlexander WBSmrcka AVRahman A Phospholipase C Epsilon Signaling Mediates Endothelial Cell Inflammation and Barrier Disruption in Acute Lung Injury.; American journal of physiology. Lung cellular and molecular physiology. 2016 Jul 1. Solleti SKSrisuma SBhattacharya SRangel-Moreno JBijli KMRandall TDRahman AMariani TJ Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Apr 8. Solleti SKSrisuma SBhattacharya SRangel-Moreno JBijli KMRandall TDRahman AMariani TJ Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation. FASEB J. 30:2615-26; . 2016 Jan 01. Solleti SKSimon DMSrisuma SArikan MCBhattacharya SRangasamy TBijli KMRahman ACrossno JTShapiro SDMariani TJ Airway epithelial cell PPARγ modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice.; American journal of physiology. Lung cellular and molecular physiology; Vol 309(3). 2015 Aug 1. Bijli KMKanter BGMinhajuddin MLeonard AXu LFazal FRahman A Regulation of endothelial cell inflammation and lung polymorphonuclear lymphocyte infiltration by transglutaminase 2.; Shock (Augusta, Ga.); Vol 42(6). 2014 Dec. Leonard AMarando CRahman AFazal F Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-κB activation and endothelial cell inflammation.; American journal of physiology. Lung cellular and molecular physiology; Vol 305(9). 2013 Nov 1. Fazal FBijli KMMurrill MLeonard AMinhajuddin MAnwar KNFinkelstein JNWatterson DMRahman A Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration.; PloS one; Vol 8(3). 2013. Bijli KMFazal FRahman A Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2.; American journal of respiratory cell and molecular biology; Vol 47(5). 2012 Nov. Yang LChen GMohanty SScott GFazal FRahman ABegum SHynes ROXu L GPR56 Regulates VEGF production and angiogenesis during melanoma progression.; Cancer research; Vol 71(16). 2011 Aug 15. Rahman AAFazal F Blocking NF-?B: An Inflammatory Issue.; Proc Am Thorac Soc 8:497-503. 2011 Jan 01. Fazal FBijli KMMinhajuddin MRein TFinkelstein JNRahman A Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells.; The Journal of biological chemistry; Vol 284(31). 2009 Jul 31. Minhajuddin MBijli KMFazal FSassano ANakayama KIHay NPlatanias LCRahman A Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells.; The Journal of biological chemistry; Vol 284(7). 2009 Feb 13. Rahman AAFazal F Hug tightly and say goodbye: Role of endothelial ICAM-1 in leukocyte transmigration.; Antioxid Redox Signal 11:823-829. 2009 Jan 01. Edirisinghe IYang SRYao HRajendrasozhan SCaito SAdenuga DWong CRahman APhipps RPJin ZGRahman I VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 22(7). 2008 Jul. Bijli KMFazal FMinhajuddin MRahman A Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65.; The Journal of biological chemistry; Vol 283(21). 2008 May 23. Garin GAbe JMohan ALu WYan CNewby ACRhaman ABerk BC Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing.; Circulation research; Vol 101(1). 2007 Jul 6. Fazal FMinhajuddin MBijli KMMcGrath JLRahman A Evidence for actin cytoskeleton-dependent and -independent pathways for RelA/p65 nuclear translocation in endothelial cells.; The Journal of biological chemistry; Vol 282(6). 2007 Feb 9. Bijli KMMinhajuddin MFazal FO'Reilly MAPlatanias LCRahman A c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells.; American journal of physiology. Lung cellular and molecular physiology; Vol 292(2). 2007 Feb. Orrington-Myers JGao XKouklis PBroman MRahman AVogel SMMalik AB Regulation of lung neutrophil recruitment by VE-cadherin.; American journal of physiology. Lung cellular and molecular physiology; Vol 291(4). 2006 Oct. Staversky RJVitiello PFGehen SCHelt CERahman AKeng PCO'Reilly MA p21(Cip1/Waf1/Sdi1) protects against hyperoxia by maintaining expression of Bcl-X(L).; Free radical biology & medicine; Vol 41(4). 2006 Aug 15. Frey RSGao XJavaid KSiddiqui SSRahman AMalik AB Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells.; The Journal of biological chemistry; Vol 281(23). 2006 Jun 9. Minhajuddin MFazal FBijli KMAmin MRRahman A Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cells.; Journal of immunology (Baltimore, Md. : 1950); Vol 174(9). 2005 May 1. Anwar KNFazal FMalik ABRahman A RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65.; Journal of immunology (Baltimore, Md. : 1950); Vol 173(11). 2004 Dec 1. Rahman AAnwar KNMinhajuddin MBijli KMJavaid KTrue ALMalik AB cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-kappaB activation and ICAM-1 expression in endothelial cells.; American journal of physiology. Lung cellular and molecular physiology; Vol 287(5). 2004 Nov. Ong ESGao XPXu NPredescu DRahman ABroman MTJho DHMalik AB E. coli pneumonia induces CD18-independent airway neutrophil migration in the absence of increased lung vascular permeability.; American journal of physiology. Lung cellular and molecular physiology; Vol 285(4). 2003 Oct. Paria BCMalik ABKwiatek AMRahman AMay MJGhosh STiruppathi C Tumor necrosis factor-alpha induces nuclear factor-kappaB-dependent TRPC1 expression in endothelial cells.; The Journal of biological chemistry; Vol 278(39). 2003 Sep 26. Kambhampati SLi YVerma ASassano AMajchrzak BDeb DKParmar SGiafis NKalvakolanu DVRahman AUddin SMinucci STallman MSFish ENPlatanias LC Activation of protein kinase C delta by all-trans-retinoic acid.; The Journal of biological chemistry; Vol 278(35). 2003 Aug 29. Deb DKSassano ALekmine FMajchrzak BVerma AKambhampati SUddin SRahman AFish ENPlatanias LC Activation of protein kinase C delta by IFN-gamma.; Journal of immunology (Baltimore, Md. : 1950); Vol 171(1). 2003 Jul 1. Javaid KRahman AAnwar KNFrey RSMinshall RDMalik AB Tumor necrosis factor-alpha induces early-onset endothelial adhesivity by protein kinase Czeta-dependent activation of intercellular adhesion molecule-1.; Circulation research; Vol 92(10). 2003 May 30. Babcock TAKurland AHelton WSRahman AAnwar KNEspat NJ Inhibition of activator protein-1 transcription factor activation by omega-3 fatty acid modulation of mitogen-activated protein kinase signaling kinases.; JPEN. Journal of parenteral and enteral nutrition; Vol 27(3). 2003 May. Rahman ATrue ALAnwar KNYe RDVoyno-Yasenetskaya TAMalik AB Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells.; Circulation research; Vol 91(5). 2002 Sep 6. Skidgel RAGao XPBrovkovych VRahman AJho DPredescu SStandiford TJMalik AB Nitric oxide stimulates macrophage inflammatory protein-2 expression in sepsis.; Journal of immunology (Baltimore, Md. : 1950); Vol 169(4). 2002 Aug 15. Frey RSRahman AKefer JCMinshall RDMalik AB PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells.; Circulation research; Vol 90(9). 2002 May 17. Uddin SSassano ADeb DKVerma AMajchrzak BRahman AMalik ABFish ENPlatanias LC Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727.; The Journal of biological chemistry; Vol 277(17). 2002 Apr 26. Gao XPStandiford TJRahman ANewstead MHolland SMDinauer MCLiu QHMalik AB Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice.; Journal of immunology (Baltimore, Md. : 1950); Vol 168(8). 2002 Apr 15. Xu NGao XPMinshall RDRahman AMalik AB Time-dependent reversal of sepsis-induced PMN uptake and lung vascular injury by expression of CD18 antagonist.; American journal of physiology. Lung cellular and molecular physiology; Vol 282(4). 2002 Apr. Fan JFrey RSRahman AMalik AB Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells.; The Journal of biological chemistry; Vol 277(5). 2002 Feb 1. Gao XXu NSekosan MMehta DMa SYRahman AMalik AB Differential role of CD18 integrins in mediating lung neutrophil sequestration and increased microvascular permeability induced by Escherichia coli in mice.; Journal of immunology (Baltimore, Md. : 1950); Vol 167(5). 2001 Sep 1. Rahman AAnwar KNUddin SXu NYe RDPlatanias LCMalik AB Protein kinase C-delta regulates thrombin-induced ICAM-1 gene expression in endothelial cells via activation of p38 mitogen-activated protein kinase.; Molecular and cellular biology; Vol 21(16). 2001 Aug. Mehta DRahman AMalik AB Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function.; The Journal of biological chemistry; Vol 276(25). 2001 Jun 22. Yang MSang HRahman AWu DMalik ABYe RD G alpha 16 couples chemoattractant receptors to NF-kappa B activation.; Journal of immunology (Baltimore, Md. : 1950); Vol 166(11). 2001 Jun 1. Kefer JRahman AAnwar KNMalik AB Decreased oxidant buffering impairs NF-kappaB activation and ICAM-1 transcription in endothelial cells.; Shock (Augusta, Ga.); Vol 15(1). 2001 Jan. Rahman AAnwar KNMalik AB Protein kinase C-zeta mediates TNF-alpha-induced ICAM-1 gene transcription in endothelial cells.; American journal of physiology. Cell physiology; Vol 279(4). 2000 Oct. Xu NRahman AMinshall RDTiruppathi CMalik AB beta(2)-Integrin blockade driven by E-selectin promoter prevents neutrophil sequestration and lung injury in mice.; Circulation research; Vol 87(3). 2000 Aug 4. True ALRahman AMalik AB Activation of NF-kB induced by H2O2 and TNFa in endothelial cells and effect on ICAM-1 expression.; Am. J. Physiol: Lung Mol. Cell. Physiolol.; Vol 279, pp. 302-311. 2000 Jan 01. Lo SKRahman AXu NZhou MYNagpala PJaffe HAMalik AB Neutrophil inhibitory factor abrogates neutrophil adhesion by blockade of CD11a and CD11b beta(2) integrins.; Molecular pharmacology; Vol 56(5). 1999 Nov. Rahman AAnwar KNTrue ALMalik AB Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion.; Journal of immunology (Baltimore, Md. : 1950); Vol 162(9). 1999 May 1. Rahman ABando MKefer JAnwar KNMalik AB Protein kinase C-activated oxidant generation in endothelial cells signals intercellular adhesion molecule-1 gene transcription.; Molecular pharmacology; Vol 55(3). 1999 Mar. Rahman AKefer JBando MNiles WDMalik AB E-selectin expression in human endothelial cells by TNFa-induced oxidant generation and NF-kB activation.; Am. J. Physiol.; Vol 19, pp. 533-544. 1998 Jan 01. Roebuck KARahman ALakshminarayanan VJanakidevi KMalik AB H2O2 and tumor necrosis factor-alpha activate intercellular adhesion molecule 1 (ICAM-1) gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter.; The Journal of biological chemistry; Vol 270(32). 1995 Aug 11. Rahman AMalhotra PDhar RKewalramani TThimmapaya B Effect of single-base substitutions in the central domain of virus-associated RNA I on its function.; Journal of virology; Vol 69(7). 1995 Jul. Fazal FRahman AHadi SM Generation of superoxide anion and hydroxyl radical by methylglyoxal.; Med. Sci. Res.; Vol 22, pp. 21-24. 1994 Jan 01. Said Ahmad MFazal FRahman AHadi SMParish JH Activities of flavonoids for the cleavage of DNA in the presence of Cu(II): correlation with generation of active oxygen species.; Carcinogenesis; Vol 13(4). 1992 Apr. Rahman AFazal FGreensill JAinley KParish JHHadi SM Strand scission in DNA induced by dietary flavonoids: role of Cu(I) and oxygen free radicals and biological consequences of scission.; Molecular and cellular biochemistry; Vol 111(1-2). 1992 Apr. Shahabuddin Rahman AHadi SM Reaction of furfural and methylfurfural with DNA: use of single-strand-specific nucleases.; Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association; Vol 29(10). 1991 Oct. Rahman AHadi SM Anticancer drugs and DNA degradation.; Med Sci Res; Vol 19, pp. 627-631. 1991 Jan 01. Fazal FRahman AGreensill JAinley KHadi SMParish JH Strand scission in DNA by quercetin and Cu(II): identification of free radical intermediates and biological consequences of scission.; Carcinogenesis; Vol 11(11). 1990 Nov. Rahman AShahabuddin Hadi SMParish JH Complexes involving quercetin, DNA and Cu(II).; Carcinogenesis; Vol 11(11). 1990 Nov. Shahabuddin Rahman AHadi SM Specificity of the in vitro interaction of methylfurfural with DNA.; Mutagenesis; Vol 5(2). 1990 Mar. Rahman AShahabuddin Hadi SM Formation of strand breaks and interstrand cross-links in DNA by methylglyoxal.; Journal of biochemical toxicology; Vol 5(3). 1990. Rahman AShahabuddin Hadi SMParish JHAinley K Strand scission in DNA induced by quercetin and Cu(II): role of Cu(I) and oxygen free radicals.; Carcinogenesis; Vol 10(10). 1989 Oct. Hadi SMShahabuddin Rehman A Specificity of the interaction of furfural with DNA.; Mutation research; Vol 225(3). 1989 Mar. Hadi SMRizvi RYRahman AUddin S Dietary mutagens and carcinogens; J Sc Ind Res; Vol 46, pp. 54-60. 1987 Jan 01. Rizvi RYUddin SRahman AHadi SM Effect of alkylation with streptozotocin on the secondary structure of DNA.; Biosc. Rep.; Vol 6, pp. 557-564. 1986 Jan 01.