Publications
Publications
- An Orai1 gain-of-function tubular aggregate myopathy mouse model phenocopies key features of the human disease.; The EMBO journal. 2024 Oct 17.
- Long-lived lung megakaryocytes contribute to platelet recovery in thrombocytopenia models.; The Journal of clinical investigation. 2024 Sep 19.
- Erythropoiesis in the mammalian embryo.; Experimental hematology. 2024 Jul 22.
- Developmental regulation of primitive erythropoiesis.; Current opinion in hematology. 2024 Feb 12.
- BMI1 regulates human erythroid self-renewal through both gene repression and gene activation.; bioRxiv : the preprint server for biology. 2024 Feb 06.
- HEXIM1 is an Essential Transcription Regulator During Human Erythropoiesis.; Blood. 2023 Sep 22.
- Yolk sac cell atlas reveals multiorgan functions during human early development.; Science (New York, N.Y.); Vol 381(6659), pp. eadd7564. 2023 Aug 18.
- Megakaryocyte NLRP3 hyperactivation induces mild anemia and potentiates inflammatory response in mice.; Frontiers in immunology; Vol 14, pp. 1226196. 2023 Aug 09.
- Transfusion of Adult, but Not Neonatal, Platelets Promotes Monocyte Trafficking in Neonatal Mice.; Arteriosclerosis, thrombosis, and vascular biology. 2023 Mar 23.
- Mammalian life depends on two distinct pathways of DNA damage tolerance.; Proceedings of the National Academy of Sciences of the United States of America; Vol 120(4), pp. e2216055120. 2023 Jan 20.
- Phenotypic and proteomic characterization of the human erythroid progenitor continuum reveal dynamic changes in cell cycle and in metabolic pathways.; American journal of hematology. 2023 Jan 06.
- Modeling human yolk sac hematopoiesis with pluripotent stem cells.; The Journal of experimental medicine; Vol 219(3). 2022 Mar 07.
- Circulating primitive murine erythroblasts undergo complex proteomic and metabolomic changes during terminal maturation.; Blood advances. 2022 Feb 09.
- Mds1CreERT2, an inducible Cre allele specific to adult-repopulating hematopoietic stem cells.; Cell reports; Vol 36(7). 2021 Aug 17.
- Histone H2A.X phosphorylation and Caspase-Initiated Chromatin Condensation in late-stage erythropoiesis.; Epigenetics & chromatin; Vol 14(1). 2021 Jul 30.
- Long-acting PGE2 and Lisinopril Mitigate H-ARS.; Radiation research. 2021 Jun 21.
- Development of Mechanical Stability in Late-Stage Embryonic Erythroid Cells: Insights From Fluorescence Imaged Micro-Deformation Studies.; Frontiers in physiology; Vol 12. 2021.
- Endothelial Cells Transition to Blood Cells but Probably Not Back Again.; Circulation research; Vol 127(10). 2020 Oct 23.
- Lung megakaryocytes are immune modulatory cells.; The Journal of clinical investigation. 2020 Oct 20.
- Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development.; Developmental cell; Vol 53(2). 2020 Apr 20.
- A human cell atlas of fetal gene expression.; Science (New York, N.Y.); Vol 370(6518). 2020 Jan 13.
- Acute and late effects of combined internal and external radiation exposures on the hematopoietic system.; International journal of radiation biology. 2019 Jul 30.
- Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B.; JCI insight; Vol 5. 2019 Apr 18.
- Inhibition of Tropomyosin Receptor Kinase A Signaling Negatively Regulates Megakaryopoiesis and induces Thrombopoiesis.; Scientific reports; Vol 9(1). 2019 Feb 26.
- Platelet-derived β2M regulates monocyte inflammatory responses.; JCI insight. 2019 Jan 31.
- Lin28b regulates age-dependent differences in murine platelet function.; Blood advances; Vol 3(1). 2019 Jan 08.
- FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity.; The Journal of biological chemistry. 2018 Oct 26.
- EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription.; Nature communications; Vol 9(1). 2018 Oct 12.
- Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.; EMBO reports. 2018 Aug 30.
- Functional Analysis of Erythroid Progenitors by Colony-Forming Assays.; Methods in molecular biology (Clifton, N.J.); Vol 1698. 2018.
- Microfluidic assay of the deformability of primitive erythroblasts.; Biomicrofluidics; Vol 11(5). 2017 Sep.
- Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating.; Scientific reports; Vol 7(1). 2017 Jul 12.
- The Ets2 repressor factor (Erf) is required for effective primitive and definitive hematopoiesis.; Molecular and cellular biology. 2017 Jul 10.
- Hematopoietic stem cell-independent hematopoiesis: emergence of erythroid, megakaryocyte, and myeloid potential in the mammalian embryo.; FEBS letters; Vol 590(22). 2016 Nov.
- Behaving better: stem cells singled out.; Blood; Vol 128(9). 2016 Sep 1.
- Delineating stages of erythropoiesis using imaging flow cytometry.; Methods (San Diego, Calif.). 2016 Aug 28.
- EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation.; Blood. 2016 Aug 1.
- Adenosine-to-insoine RNA editing by ADAR1 is essential for normal murine erythropoiesis.; Experimental hematology. 2016 Jun 30.
- Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity.; Stem cells (Dayton, Ohio); Vol 34(2). 2016 Feb.
- Imaging Flow Cytometric Analysis of Primary Bone Marrow Megakaryocytes.; Methods in molecular biology (Clifton, N.J.); Vol 1389. 2016.
- Interaction of the Macrophage and Primitive Erythroid Lineages in the Mammalian Embryo.; Frontiers in immunology; Vol 7. 2016.
- Early hematopoiesis and macrophage development.; Seminars in immunology; Vol 27(6). 2015 Dec.
- A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis.; PLoS genetics; Vol 11(10). 2015 Oct.
- Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation.; Blood; Vol 126(12). 2015 Sep 17.
- Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo.; Cell reports; Vol 11(12). 2015 Jun 30.
- Bmi-1 Regulates Extensive Erythroid Self-Renewal.; Stem cell reports; Vol 4(6). 2015 Jun 9.
- Stochastic modeling of stress erythropoiesis using a two-type age-dependent branching process with immigration.; Journal of mathematical biology; Vol 70(7). 2015 Jun.
- The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.; Science signaling; Vol 8(372). 2015 Apr 14.
- Environmentally-defined enhancer populations regulate diversity of tissue-resident macrophages.; Trends in immunology; Vol 36(2). 2015 Feb.
- Interleukin-12 preserves the cutaneous physical and immunological barrier after radiation exposure.; Radiation research; Vol 183(1). 2015 Jan.
- Persistence of cisplatin-induced mutagenicity in hematopoietic stem cells: implications for secondary cancer risk following chemotherapy.; Toxicological sciences : an official journal of the Society of Toxicology; Vol 140(2). 2014 Aug 1.
- SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury.; Blood; Vol 124(2). 2014 Jul 10.
- Extensively self-renewing erythroblasts derived from transgenic β-yac mice is a novel model system for studying globin switching and erythroid maturation.; Experimental hematology; Vol 42(7). 2014 Jul.
- Of mice and men….; Blood; Vol 123(22). 2014 May 29.
- Improved quantitative analysis of primary bone marrow megakaryocytes utilizing imaging flow cytometry.; Cytometry. Part A : the journal of the International Society for Analytical Cytology; Vol 85(4). 2014 Apr.
- Primitive and definitive erythropoiesis in mammals.; Frontiers in physiology; Vol 5. 2014.
- Preface to issue on embryonic and fetal hematopoiesis.; Blood cells, molecules & diseases; Vol 51(4). 2013 Dec.
- Erythro-myeloid progenitors: "definitive" hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells.; Blood cells, molecules & diseases; Vol 51(4). 2013 Dec.
- Erythropoietin critically regulates the terminal maturation of murine and human primitive erythroblasts.; Haematologica; Vol 98(11), pp. 1778-87. 2013 Jul 26.
- Development of membrane mechanical function during terminal stages of primitive erythropoiesis in mice.; Experimental hematology; Vol 41(4). 2013 Apr.
- Ontogeny of erythroid gene expression.; Blood; Vol 121(6). 2013 Feb 7.
- EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress.; Blood; Vol 120(12). 2012 Sep 20.
- Losing a "nucleus" to gain a cytoplasm.; Blood; Vol 119(25). 2012 Jun 21.
- A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo.; Blood; Vol 117(17). 2011 Apr 28.
- Sublethal radiation injury uncovers a functional transition during erythroid maturation.; Experimental hematology; Vol 39(4). 2011 Apr.
- Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus.; Blood; Vol 117(9). 2011 Mar 3.
- Blood in a dish: In vitro synthesis of red blood cells.; Drug discovery today. Disease mechanisms; Vol 8(1-2). 2011.
- Interaction of retinoic acid and scl controls primitive blood development.; Blood; Vol 116(2). 2010 Jul 15.
- Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.; Toxicological sciences : an official journal of the Society of Toxicology; Vol 115(2). 2010 Jun.
- Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.; Toxicological sciences : an official journal of the Society of Toxicology; Vol 114(1). 2010 Mar.
- Primitive erythropoiesis in the mammalian embryo.; The International journal of developmental biology; Vol 54(6-7). 2010.
- Transient glutathione depletion determines terminal differentiation in HL-60 cells.; Oxidative medicine and cellular longevity; Vol 3(1). 2010 Jan.
- Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.; Cell metabolism; Vol 10(2). 2009 Aug.
- Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age.; Mutation research; Vol 675(1-2). 2009 Apr 30.
- 15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes.; Blood; Vol 112(10). 2008 Nov 15.
- Multispectral imaging of hematopoietic cells: where flow meets morphology.; Journal of immunological methods; Vol 336(2). 2008 Jul 31.
- Ontogeny of erythropoiesis.; Current opinion in hematology; Vol 15(3). 2008 May.
- All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac.; Blood; Vol 111(7). 2008 Apr 1.
- Primitive erythropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb.; Blood; Vol 111(5). 2008 Mar 1.
- Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus.; Blood; Vol 111(4). 2008 Feb 15.
- A heme export protein is required for red blood cell differentiation and iron homeostasis.; Science (New York, N.Y.); Vol 319(5864). 2008 Feb 8.
- Ontogeny of erythropoiesis in the mammalian embryo.; Current topics in developmental biology; Vol 82. 2008.
- Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry.; Mutation research; Vol 634(1-2). 2007 Dec 01.
- The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis.; Blood; Vol 109(4). 2007 Feb 15.
- "Maturational" globin switching in primary primitive erythroid cells.; Blood; Vol 107(4). 2006 Feb 15.
- Sox6 directly silences epsilon globin expression in definitive erythropoiesis.; PLoS genetics; Vol 2(2). 2006 Feb.
- Hematopoiesis in the yolk sac: more than meets the eye.; Experimental hematology; Vol 33(9). 2005 Sep.
- Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.; Nature; Vol 436(7053). 2005 Aug 18.
- Analysis of hematopoietic progenitors in the mouse embryo.; Methods in molecular medicine; Vol 105. 2005.
- Haemangioblast commitment is initiated in the primitive streak of the mouse embryo.; Nature; Vol 432(7017). 2004 Dec 2.
- The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis.; PLoS biology; Vol 2(8). 2004 Aug.
- Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis.; Blood; Vol 104(1). 2004 Jul 1.
- cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes.; Nature; Vol 425(6955). 2003 Sep 18.
- Circulation is established in a stepwise pattern in the mammalian embryo.; Blood; Vol 101(5). 2003 Mar 1.
- Onset of cardiac function during early mouse embryogenesis coincides with entry of primitive erythroblasts into the embryo proper.; Circulation research; Vol 92(2). 2003 Feb 7.
- Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression.; Development (Cambridge, England); Vol 129(23). 2002 Dec.
- Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro.; Blood; Vol 100(2). 2002 Jul 15.
- Angiocentric T-cell lymphoma of the temporal bone.; Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery; Vol 126(1). 2002 Jan.
- Yolk-sac hematopoiesis: the first blood cells of mouse and man.; Experimental hematology; Vol 29(8). 2001 Aug.
- Regulation of hemangioblast development.; Annals of the New York Academy of Sciences; Vol 938. 2001 Jun.