Post-Doctoral Fellows and Students
Research Interest:
Investigating differential intron sensitivity to PUF60, a gene that is deleted or amplified in developmental syndromes and cancers
Research Interest:
Development of gene delivery techniques to the lung using electroporation and modified nucleic acids
Research Interest:
The Effect of Integrator Subunit 11 Mutations on Integrator Function and Neuronal Development
Research Interest: Understanding the role of lncRNA Neat1 in maintaining cell identity.
Research Interest:
Pathomechanism of skeletal muscle weakness and degeneration in Myotonic Dystrophy
Research Interest:
Investigating the roles of the SF3B1 ULMs in recruiting protein phosphatases for pre-mRNA splicing
Research Interest:
Translational control and metabolism
Research Interest:
Understanding the mechanism of pre-mRNA splicing regulation by the long non-coding RNA Neat1.
Research Interest:
Suppression of cerebral cavernous malformation nonsense mutation using anti-codon edited tRNAs
Research Interest:
Development of tools and tRNA-based therapeutics for rescue of PTC-derived disease and improved target protein expression
Research Interest:
Characterizaon of KCNE6 and KCNE7: Novel Regulators of Cardiac Repolarizaon Channels KCNQ1 and hERG
Research Interest:
Evidence for a non-canonical mode of translation regulation by preQ1 riboswitches
Research Interest:
mRNA degradosomes, tRNA processing and penicillin binding proteins-4 as targets to develop novel classes of antibacterial drugs.
Research Interest:
Investigating the Role of RNA Helicases in Splicing Changes caused by Cancer Associated SF3B1 Mutations
Research Interest:
Identification and Characterization of Transcription Factors Associating with the Integrator Complex
Research Interest:
Modeling the effects of cancer-associated spliceosome mutations and identifying driving intronic features using deep-learning neural networks
Research Interest:
Developing novel thermodynamic parameters for RNA folding stability in simulated cellular environments to improve the accuracy of RNA secondary structure predictions.
Research Interest:
Modeling CDK12 and CDK13 Loss-of-Function to Investigate Their Roles in Alternative Polyadenylation and Neoantigen Expression
Research Interest:
Cytoplasmic Assembly of Nuclear RNA Endonucleases
Research Interest:
Structural Studies of Cas13b Accessory Protein Csx27
Research Interest:
Structure and Function Analysis of a Type III PreQ1 Riboswitch from Escherichia coli
Research Interest:
Structural Investigation of Early Splicing Factor Complexes
Research Interest:
Pulling the plug on bacteriophage infection: investigating the molecular mechanism of activation of CRISPR-Csx28
Research Interest:
Structure and Function Analysis of a Spermidine-Sensing Bacterial Riboswitch
Research Interest:
Regulation of transcription machinery by phosphorylation
Research Interest:
Targeting A. baumannii efflux pumps via small molecule inhibitors to improve existing antibiotic treatments' effectiveness and combat adaptive efflux-mediated drug resistance.
Research Interest:
Predicting conserved non-canonical RNA interactions using sequence comparison
Research Interest:
The role of the Type VI CRISPR-Cas accessory protein Csx27 in CRISPR-Cas13 mediated anti-viral immunity
Research Interest:
Defining the roles of 5’UTR length and secondary structure in eukaryotic translation initiation
Research Interest:
Targeted pseudouridylation identifies a novel Ψ-Ψ codon-anticodon pairing in nonsense suppression and translational recoding
Research Interest:
Nucleic Acid Biology, Epigenetics, and Development. My project is focused on the role of H2A.Z in epigenetic inheritance.
Research Interest:
The function of lncRNAs in heart development; optimizing techniques to identify direct protein interactions with lncRNAs.
Research Interest:
Developing a platform for experimental identification of genetic barriers to horizontal gene transfer in Staphylococcus aureus
Research Interest:
Elucidating the Epigenetic Mechanisms that Regulate stress and steady-state Erythropoiesis, with the overarching goal of ameliorating symptoms in hemoglobinopathies.
Research Interest:
Characterizing the RNA backbone can highlight important features common across structures
Research Interest:
Type VI CRISPR and associated bacterial anti-phage defense systems
Research Interest:
Isolating the Role of Myotonia in Myotonic Dystrophy Pathogenesis
Research Interest:
Structure and Function Analysis of Bacterial Riboswitches that Control Translation
Research Interest:
In Vitro Selection Identifies Cardiac Cell Targeting RNA Motifs/p>
