Faculty
Aging & Stress Cancer Biology Cell & Developmental Biology Disease Models Genomics & Bioinformatics Neurobiology RNA Biology
Affiliated Faculty
Research Interest:
Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.
Pharmacology & Physiology
Research Interest: LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.
Research Interest: Molecular mechanisms of cancer stem cell interactions with tumor microenvironment in disease progression
Pharmacology & Physiology
Neurology
Research Interest:
Signaling transduction mechanisms in the vascular system
Research Interest: Molecular and Cellular Mechanisms that Control Tissue Homeostasis and Somatic Stem Cells
Research Interest:
The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease
Dr. Bohmann works part-time and doesn’t accept new students.
Research Interest: Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.
Biochemistry & Biophysics
Research Interest: Chromatin domains and long-range activation by enhancers
Research Interest:
Understanding the interaction of HIV with glial cells; Developing an improved live attenuated influenza vaccine (LAIV); Elucidating the host cell response to infection by viral pathogens (with emphasis on SARS-CoV-2 and Adeno-associated virus, AAV)
Pharmacology & Physiology
Research Interest:
Our research interests span three areas including epigenetic mechanisms of mitotic cell division, chromatin, heterochromatin, histone variants and modifications; biomineralization of odontogenic tissues and finally generating tools for engineering and regeneration of complex periodontal tissues.
Biochemistry & Biophysics
Research Interest: Signal transduction; membrane protein structure, yeast molecular biology
Biochemistry & Biophysics
Research Interest:
Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Research Interest: Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.
Plasticity of aging, stress response, and metabolism, as well as behavioral plasticity.
Research Interest:
Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.
Mitochondrial Research and Innovation Group
Biomedical GeneticsResearch Interest:
Understanding the roles of antioxidants in disease
William A. Bernhard Memorial Lab
Biochemistry & BiophysicsResearch Interest: Regulation of transcription, nuclear processes, related to chromatin structure and function
Medicine
Research Interest: The molecular biology and genetics of pancreatic and biliary tract cancers
Flaum Eye Institute
Biomedical Genetics
Research Interest: Molecular development of the eye and inner ear; anterior segment dysgenesis (ASD) and developmental glaucoma; congenital deafness and vestibular dysfunction
Biomedical Genetics
Research Interest: Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Research Interest: Satellite DNA (repetitive DNA typically found at centromeres and telomeres), Meiotic Drive, and Selfish DNA using genomic, population genetic, molecular and cytological methods.
Flaum Eye Institute
Ophthalmology
Research Interest: Neurobiology of glaucoma, molecular processes that lead to retinal ganglion cell death.
Research Interest:
Functional genome of aging and age-related diseases, with specific focus on human genetic variation, epigenome, and 3D genome, by leveraging the power of large-scale biobanks, single-cell multi-omics technologies, machine-learning/AI models and molecular experiments.
Research Interest:
RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Medicine
Environmental Medicine
Pediatrics
Research Interest:
Genetic and environmental susceptibility to developmental lung injury
Research Interest: Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Biomedical Genetics
Research Interest: Identification of different stem and precursor cell pools in CNS that may be critical for cell replacement therapies or are targets of insults that lead to developmental pathologies.
Biostatistics & Computational Biology
Research Interest:
Developing methods to estimate gene regulatory networks from gene perturbation experiments
Research Interest: Analysis of gene regulatory networks in cancer; role of immunogenetics in transplant
Research Interest: Understanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation.
Research Interest:
The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.
Mitochondrial Research and Innovation Group
Pharmacology & PhysiologyMedicine
Research Interest: Integrative Physiology
Research Interest: Neuro stem cell biology and medicine, developing pharmacological and cell based approaches to peripheral and spinal cord injury.
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Environmental Medicine
Research Interest:
Defining how an aberrant oxygen environment and oxygen-induced DNA damage signaling alter distal lung development, the host response to respiratory viral infections, and promotes cardiovascular disease later in life
Biomedical Genetics
Neurology
Pediatrics
Research Interest: Pediatric Neurology, Human Genetics
Pediatrics
Research Interest: Cellular and Molecular events underlying the ontogeny of the hematopoietic system.
Research Interest: Genetic mechanisms in acute myeloid leukemia and myelodysplastic syndrome with focus on the zinc finger oncoprotein EVI1
Research Interest: tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.
Biomedical Genetics
Biology
Research Interest: Neural circuit development and function; Genetic control of behavior; Sex differences in neurobiology
Research Interest:
Using primarily human pluripotent stem cell models, we examine astrocyte development in normal and pathological conditions, the role of astrocytes in modulating response to injury or stress, the role of altered RNA processing and translation in neural development, and the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy.
Environmental Medicine
Research Interest: Experimental platform using the amphibian Xenopus for research in immunotoxicology, fundamental and medical immunology
Mitochondrial Research and Innovation Group
Biomedical GeneticsMicrobiology & Immunology
Research Interest:
The role of metabolism in lineage differentiation
Research Interest:
Innate cell antiviral responses, allergic inflammation, mucosal/airway immunity, vaccine responses
Research Interest: Understanding the genetic, cell biological and molecular basis for age-driven proteostatic deterioration
Urology
Medicine
Biomedical Engineering
Microbiology & Immunology
Orthopaedics
Research Interest: Inflammatory bone loss as seen in rheumatoid arthritis, infections, tumor metastasis and wear debris induced osteolysis around prosthetic implants
Biomedical Genetics
Ophthalmology
Research Interest:
Using patient-derived human induced pluripotent stem cells (hiPSCs) to study the molecular mechanism of specific retinal and neurological diseases and applying that knowledge to pharmacologically target certain retinal disorders in patient-derived cells.
Pharmacology & Physiology
Biomedical Engineering
Research Interest:
Cellular and molecular mechanisms of heart development, disease, and regeneration; Transcriptional regulation of fibroblast plasticity and cardiac fibrosis
Neuroscience
Research Interest:
Neurotoxicology, Etiology of neurobehavioral disease, Endocrine dysfunction, Synergistic Toxicity.
Medicine
Research Interest:
Understanding how regulation of RNA Polymerase II activity regulates cellular differentiation, with a focus on erythropoiesis. Delineating epigenetic control of normal erythropoiesis; determining the contribution of disrupted epigenetic regulation to inherited anemias.
Neuroscience
Research Interest:
Understanding the neural circuit mechanisms that generate and shape complex feeding behaviors
Research Interest:
Our research program focuses on mechanisms underlying gene environment interaction in pregnancy. We are interested in elucidating how environmental factors influence epigenetic regulation of developmental-relevant genes including imprinted genes, and how exposure modulates maternal-fetal health.
Flaum Eye Institute
Neuroscience
Pharmacology & Physiology
Research Interest:
Retinal degeneration and maladaptive plasticity in inner retinal circuits.
Program for Advanced Immune Bioimaging
Microbiology & ImmunologyResearch Interest: Systems approach utilizing bioinformatics, and dynamic modeling tools to study immune response to infections and vaccination.
Neuroscience
Research Interest: Myotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.
Research Interest: Cancer epigenetics: the role of DNA methylation and chromatin in driving cancer phenotypes and as a target for therapeutic intervention
Research Interest:
Cell biology, biochemistry, and molecular genetics; Organelle biogenesis; Organelle degradation through selective autophagy; Organelle aging and neurodegeneration; Cellular stress response
Research Interest: How microtubule motors, such as kinesins and dyneins, transport organelles and other cargoes throughout the cell.
Mitochondrial Research and Innovation Group
Biochemistry & BiophysicsMedicine
Research Interest:
Pathophysiological function and molecular mechanism of new non-coding RNAs and RNA-binding proteins and translational control in cardiac system and cardiovascular disease
Research Interest: Signal transduction and development of therapeutic agents in B-lymphomas; Cell cycle regulation