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Biomedical Genetics and Genomics

Education / Graduate Education / PhD Programs / Biomedical Genetics and Genomics / Faculty & Students / Faculty

 

Faculty

Aging & Stress Cancer Biology Cell & Developmental Biology Disease Models Genomics & Bioinformatics Neurobiology RNA Biology

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Affiliated Faculty

Brian Altman, Ph.D.
Brian Altman, Ph.D.

Altman Lab

Biomedical Genetics
Research Interest:

Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism. 


Douglas Anderson, Ph.D.
Douglas Anderson, Ph.D.

Anderson Lab

Medicine
Pharmacology & Physiology
Research Interest: LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.

Jeevisha Bajaj, Ph.D.
Jeevisha Bajaj, Ph.D.

Bajaj Lab

Biomedical Genetics
Research Interest: Molecular mechanisms of cancer stem cell interactions with tumor microenvironment in disease progression

Bradford Berk, M.D., Ph.D.
Bradford Berk, M.D., Ph.D.

Berk Lab

Medicine
Pharmacology & Physiology
Neurology
Research Interest:

Signaling transduction mechanisms in the vascular system


Xin Bi, Ph.D.
Xin Bi, Ph.D.

Bi Lab

Biology
Research Interest: Chromatin-mediated regulation of gene expression in eukaryotes.

Benoit Biteau, Ph.D.
Benoit Biteau, Ph.D.

Biteau Lab

Biomedical Genetics
Research Interest: Molecular and Cellular Mechanisms that Control Tissue Homeostasis and Somatic Stem Cells

Dirk Bohmann, Ph.D.
Dirk Bohmann, Ph.D.
Biomedical Genetics
Research Interest:

The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease

Dr. Bohmann works part-time and doesn’t accept new students.


Paul Boutz, Ph.D.
Paul Boutz, Ph.D.

Boutz Lab

Biochemistry & Biophysics
Research Interest: Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.

Michael Bulger, Ph.D.
Michael Bulger, Ph.D.

Bulger Lab

Pediatrics
Biochemistry & Biophysics
Research Interest: Chromatin domains and long-range activation by enhancers

Stephen Dewhurst, Ph.D.
Stephen Dewhurst, Ph.D.

Dewhurst Lab

Microbiology & Immunology
Research Interest:

Understanding the interaction of HIV with glial cells; Developing an improved live attenuated influenza vaccine (LAIV); Elucidating the host cell response to infection by viral pathogens (with emphasis on SARS-CoV-2 and Adeno-associated virus, AAV)


Thomas Diekwisch, D.M.D., Ph.D., Ph.D.
Thomas Diekwisch, D.M.D., Ph.D., Ph.D.

Diekwisch Lab

Oral and Cranial Facial Sciences
Pharmacology & Physiology
Research Interest:

Our research interests span three areas including epigenetic mechanisms of mitotic cell division, chromatin, heterochromatin, histone variants and modifications;  biomineralization of odontogenic tissues and finally generating tools for engineering and regeneration of complex periodontal tissues.


Mark Dumont, Ph.D.
Mark Dumont, Ph.D.

Dumont Lab

Pediatrics
Biochemistry & Biophysics
Research Interest: Signal transduction; membrane protein structure, yeast molecular biology

Dmitri Ermolenko, Ph.D.
Dmitri Ermolenko, Ph.D.

Ermolenko Lab

Biology
Biochemistry & Biophysics
Research Interest:

Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.


Robert Freeman, Ph.D.
Robert Freeman, Ph.D.

Freeman Lab

Pharmacology & Physiology
Research Interest: Molecular biology of programmed cell death

Dragony Fu, Ph.D.
Dragony Fu, Ph.D.

Fu Lab

Biology
Research Interest: Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.

Karl Glastad, Ph.D.
Karl Glastad, Ph.D.
Research Interest:

Plasticity of aging, stress response, and metabolism, as well as behavioral plasticity.


Vera Gorbunova, Ph.D.
Vera Gorbunova, Ph.D.

Gorbunova & Seluanov Lab

Biology
Research Interest:

Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.


Jeffrey Hayes, Ph.D.
Jeffrey Hayes, Ph.D.

William A. Bernhard Memorial Lab

Hayes Lab

Biochemistry & Biophysics
Research Interest: Regulation of transcription, nuclear processes, related to chromatin structure and function

Aram Hezel, M.D.
Aram Hezel, M.D.
Biomedical Genetics
Medicine
Research Interest: The molecular biology and genetics of pancreatic and biliary tract cancers

Amy Kiernan, Ph.D.
Amy Kiernan, Ph.D.

Kiernan Lab

Ophthalmology
Flaum Eye Institute
Biomedical Genetics
Research Interest: Molecular development of the eye and inner ear; anterior segment dysgenesis (ASD) and developmental glaucoma; congenital deafness and vestibular dysfunction

Hartmut Land, Ph.D.
Hartmut Land, Ph.D.

Land Lab

Biochemistry & Biophysics
Biomedical Genetics
Research Interest: Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism

Amanda Larracuente, Ph.D.
Amanda Larracuente, Ph.D.

Larracuente Lab

Biology
Research Interest: Satellite DNA (repetitive DNA typically found at centromeres and telomeres), Meiotic Drive, and Selfish DNA using genomic, population genetic, molecular and cytological methods.

Richard Libby, Ph.D.
Richard Libby, Ph.D.

Libby Lab

Biomedical Genetics
Flaum Eye Institute
Ophthalmology
Research Interest: Neurobiology of glaucoma, molecular processes that lead to retinal ganglion cell death.

Hongbo Liu, Ph.D.
Hongbo Liu, Ph.D.

Liu Lab

Biomedical Genetics
Research Interest:

Functional genome of aging and age-related diseases, with specific focus on human genetic variation, epigenome, and 3D genome, by leveraging the power of large-scale biobanks, single-cell multi-omics technologies, machine-learning/AI models and molecular experiments.


Alayna Loiselle, Ph.D.
Alayna Loiselle, Ph.D.

Loiselle Lab

Orthopaedics
Research Interest:

Musculoskeletal tissue regeneration


Lynne Maquat, Ph.D.
Lynne Maquat, Ph.D.

Maquat Lab

Biochemistry & Biophysics
Research Interest:

RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.


Thomas Mariani, Ph.D.
Thomas Mariani, Ph.D.

Mariani Lab

Biomedical Genetics
Medicine
Environmental Medicine
Pediatrics
Research Interest:

Genetic and environmental susceptibility to developmental lung injury


David Mathews, M.D., Ph.D.
David Mathews, M.D., Ph.D.

Mathews Lab

Biochemistry & Biophysics
Research Interest: Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.

Margot Mayer-Pröschel, Ph.D.
Margot Mayer-Pröschel, Ph.D.

Mayer-Pröschel Lab

Neuroscience
Biomedical Genetics
Research Interest: Identification of different stem and precursor cell pools in CNS that may be critical for cell replacement therapies or are targets of insults that lead to developmental pathologies.

Matthew McCall, Ph.D.
Matthew McCall, Ph.D.
Biomedical Genetics
Biostatistics & Computational Biology
Research Interest:

Developing methods to estimate gene regulatory networks from gene perturbation experiments


Helene McMurray, Ph.D.
Helene McMurray, Ph.D.

McMurray Lab

Pathology & Laboratory Medicine
Research Interest: Analysis of gene regulatory networks in cancer; role of immunogenetics in transplant

Stephano Mello, Ph.D.
Stephano Mello, Ph.D.

Mello Lab

Biomedical Genetics
Research Interest: Understanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation.

Patrick Murphy, Ph.D.
Patrick Murphy, Ph.D.

Patrick Murphy Lab

Biomedical Genetics
Research Interest:

The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.


Mark Noble, Ph.D.
Mark Noble, Ph.D.

Noble Lab

Biomedical Genetics
Research Interest: Neuro stem cell biology and medicine, developing pharmacological and cell based approaches to peripheral and spinal cord injury.

Mitchell O'Connell, Ph.D.
Mitchell O'Connell, Ph.D.

O'Connell Lab

Biochemistry & Biophysics
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development

Michael O'Reilly, Ph.D.
Michael O'Reilly, Ph.D.

O'Reilly Lab

Pediatrics
Environmental Medicine
Research Interest:

Defining how an aberrant oxygen environment and oxygen-induced DNA damage signaling alter distal lung development, the host response to respiratory viral infections, and promotes cardiovascular disease later in life


James Palis, M.D.
James Palis, M.D.

Palis Lab

Biomedical Genetics
Pediatrics
Research Interest: Cellular and Molecular events underlying the ontogeny of the hematopoietic system.

Archibald Perkins, M.D., Ph.D.
Archibald Perkins, M.D., Ph.D.

Perkins / Zhang Lab

Pathology & Laboratory Medicine
Research Interest: Genetic mechanisms in acute myeloid leukemia and myelodysplastic syndrome with focus on the zinc finger oncoprotein EVI1

Eric Phizicky, Ph.D.
Eric Phizicky, Ph.D.

Phizicky Lab

Biochemistry & Biophysics
Research Interest: tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.

Douglas Portman, Ph.D.
Douglas Portman, Ph.D.

Portman Lab

Neuroscience
Biomedical Genetics
Biology
Research Interest: Neural circuit development and function; Genetic control of behavior; Sex differences in neurobiology

Christoph Pröschel, Ph.D.
Christoph Pröschel, Ph.D.

Pröschel Lab

Biomedical Genetics
Research Interest:

Using primarily human pluripotent stem cell models, we examine astrocyte development in normal and pathological conditions, the role of astrocytes in modulating response to injury or stress, the role of altered RNA processing and translation in neural development, and the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy.


Jacques Robert, Ph.D.
Jacques Robert, Ph.D.

Robert Lab

Microbiology & Immunology
Environmental Medicine
Research Interest: Experimental platform using the amphibian Xenopus for research in immunotoxicology, fundamental and medical immunology

Regina Rowe, M.D., Ph.D.
Regina Rowe, M.D., Ph.D.

Rowe Lab

Pediatrics
Research Interest:

Innate cell antiviral responses, allergic inflammation, mucosal/airway immunity, vaccine responses


Andrew Samuelson, Ph.D.
Andrew Samuelson, Ph.D.

Samuelson Lab

Biomedical Genetics
Research Interest: Understanding the genetic, cell biological and molecular basis for age-driven proteostatic deterioration

Edward Schwarz, Ph.D.
Edward Schwarz, Ph.D.

Schwarz Lab

Pathology & Laboratory Medicine
Urology
Medicine
Biomedical Engineering
Microbiology & Immunology
Orthopaedics
Research Interest: Inflammatory bone loss as seen in rheumatoid arthritis, infections, tumor metastasis and wear debris induced osteolysis around prosthetic implants

Ruchira Singh, Ph.D.
Ruchira Singh, Ph.D.

Singh Lab

Flaum Eye Institute
Biomedical Genetics
Ophthalmology
Research Interest:

Using patient-derived human induced pluripotent stem cells (hiPSCs) to study the molecular mechanism of specific retinal and neurological diseases and applying that knowledge to pharmacologically target certain retinal disorders in patient-derived cells.


Eric Small, Ph.D.
Eric Small, Ph.D.

Small Lab

Medicine
Pharmacology & Physiology
Biomedical Engineering
Research Interest:

Cellular and molecular mechanisms of heart development, disease, and regeneration; Transcriptional regulation of fibroblast plasticity and cardiac fibrosis


Marissa Sobolewski-Terry, Ph.D.
Marissa Sobolewski-Terry, Ph.D.

Sobolewski Lab

Environmental Medicine
Neuroscience
Research Interest:

Neurotoxicology, Etiology of neurobehavioral disease, Endocrine dysfunction, Synergistic Toxicity.


Laurie Steiner, M.D.
Laurie Steiner, M.D.

Steiner Lab

Pediatrics
Medicine
Research Interest:

Understanding how regulation of RNA Polymerase II activity regulates cellular differentiation, with a focus on erythropoiesis. Delineating epigenetic control of normal erythropoiesis; determining the contribution of disrupted epigenetic regulation to inherited anemias.


Gabriella Sterne, PhD
Gabriella Sterne, PhD

Sterne Lab

Biomedical Genetics
Neuroscience
Research Interest:

Understanding the neural circuit mechanisms that generate and shape complex feeding behaviors


Martha Susiarjo, Ph.D.
Martha Susiarjo, Ph.D.

Susiarjo Lab

Environmental Medicine
Research Interest:

Our research program focuses on mechanisms underlying gene environment interaction in pregnancy. We are interested in elucidating how environmental factors influence epigenetic regulation of developmental-relevant genes including imprinted genes, and how exposure modulates maternal-fetal health.


Michael Telias, Ph.D.
Michael Telias, Ph.D.

Telias Lab

Ophthalmology
Flaum Eye Institute
Neuroscience
Pharmacology & Physiology
Research Interest:

Retinal degeneration and maladaptive plasticity in inner retinal circuits.


Juilee Thakar, Ph.D.
Juilee Thakar, Ph.D.

Thakar Lab

Program for Advanced Immune Bioimaging

Microbiology & Immunology
Research Interest: Systems approach utilizing bioinformatics, and dynamic modeling tools to study immune response to infections and vaccination.

Charles Thornton, M.D.
Charles Thornton, M.D.

Thornton Lab

Neurology
Neuroscience
Research Interest: Myotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.

Paula Vertino, Ph.D.
Paula Vertino, Ph.D.

Vertino Lab

Biomedical Genetics
Research Interest: Cancer epigenetics: the role of DNA methylation and chromatin in driving cancer phenotypes and as a target for therapeutic intervention

Ning Wang, PhD
Ning Wang, PhD

Ning-Wang Lab

Biology
Research Interest:

Cell biology, biochemistry, and molecular genetics; Organelle biogenesis; Organelle degradation through selective autophagy; Organelle aging and neurodegeneration; Cellular stress response


Michael Welte, Ph.D.
Michael Welte, Ph.D.

Welte Lab

Biology
Research Interest: How microtubule motors, such as kinesins and dyneins, transport organelles and other cargoes throughout the cell.

Jack Werren, Ph.D.
Jack Werren, Ph.D.
Biology
Research Interest: Evolutionary Genetics

Peng Yao, Ph.D.
Peng Yao, Ph.D.

Yao Lab

Mitochondrial Research and Innovation Group

Biochemistry & Biophysics
Medicine
Research Interest:

Pathophysiological function and molecular mechanism of new non-coding RNAs and RNA-binding proteins and translational control in cardiac system and cardiovascular disease


Jiyong Zhao, Ph.D.
Jiyong Zhao, Ph.D.

Land Lab

Zhao Lab

Biomedical Genetics
Research Interest: Signal transduction and development of therapeutic agents in B-lymphomas; Cell cycle regulation