Faculty
Affiliated Faculty
Research Interest:
Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.
Microbiology & Immunology
Medicine
Research Interest: The role of B cells in the pathophysiology of human systemic lupus and rheumatoid arthritis and the study of new immuno-modulatory treatments
Research Interest: Molecular mechanisms of cancer stem cell interactions with tumor microenvironment in disease progression
Pathology & Laboratory Medicine
Research Interest: Lysosomal and mitochondrial dysfunction in neurodegenerative diseases
Mitochondrial Research and Innovation Group
Anesthesiology and Perioperative MedicinePharmacology & Physiology
Research Interest: Cardioprotection against ischemia-reperfusion (IR) injury. Role of Mitochondria and metabolism in ischemic preconditioning and anesthetic preconditioning.
Pharmacology & Physiology
Neurosurgery
Research Interest: Cellular and Molecular Mechanisms of Microenvironmental Regulation of Hematopoietic Stem Cells in the Bone Marrow
Pharmacology & Physiology
Research Interest:
The role of CAv 1, 2 in tendon formation and heterotopic bone (HO) formation
Research Interest: My laboratory studies cancer biology with an emphasis in developmental therapeutics and pancreatic cancer metastasis and dormancy
Orthopaedics
Research Interest:
Research Interest: Elucidating the Mechanisms of Disease-related Skeletal Muscle Wasting with the goal of discovering viable therapies that will improve patients’ quality of life, and treatment outcomes related to the underlying pathology.
Biomedical Engineering
Pediatrics
Research Interest: Molecular mechanisms of gene delivery and development of gene therapies for lung disease
Pharmacology & Physiology
Research Interest:
Our research interests span three areas including epigenetic mechanisms of mitotic cell division, chromatin, heterochromatin, histone variants and modifications; biomineralization of odontogenic tissues and finally generating tools for engineering and regeneration of complex periodontal tissues.
Research Interest: Toxicology of inhaled ultrafine particles (UFPs) on the lung, cardiovascular and central nervous system
Mitochondrial Research and Innovation Group
OrthopaedicsPharmacology & Physiology
Research Interest:
Role of Mitochondria in regulation of cell fate in normal stem cells and cancer cells
Pediatrics
Research Interest:
Understanding the pathogenesis of Acute Lung Injury (ALI), a life threatening pulmonary inflammatory condition
Research Interest: Role of inflammatory mediators in bone marrow microenvironmental dysfunction during hematologic malignancies
Program for Advanced Immune Bioimaging
Microbiology & ImmunologyEnvironmental Medicine
Medicine
Research Interest:
Defining molecular pathways by which allergens and particulates activate epithelia and dendritic cells in the lung immune system
Center for Tumor Immunology Research
Microbiology & ImmunologySurgery
Research Interest: The Gerber lab studies tumor immunology with a focus on harnessing the immune system to recognize and kill cancerous cells utilizing an immunotherapeutic approach to enhance the efficacy of chemo/radiotherapies to control or even cure both primary and metastatic malignancies.
Biomedical Engineering
Research Interest: Role of cell-cell contact in regulating cellular function in both the normal and disease state
Research Interest:
Basic biological mechanisms of circadian synchrony and entrainment in health and disease. Understanding how circadian rhythms and sleep can enhance glymphatic, neuronal, and cerebrovascular function.
Mitochondrial Research and Innovation Group
Biomedical GeneticsPharmacology & Physiology
Research Interest:
Understanding the roles of antioxidants in disease
Otolaryngology
Research Interest:
Synaptic pharmaco-physiology of vestibular efferent-afferent interactions
Mitochondrial Research and Innovation Group
Pharmacology & PhysiologyAnesthesiology and Perioperative Medicine
Research Interest:
Molecular mechanisms of Neurodegeneration
Pediatrics
Research Interest:
Development of the infant microbiome and immune system, and how that relates to development of allergic diseases
Flaum Eye Institute
Biomedical Genetics
Research Interest: Molecular development of the eye and inner ear; anterior segment dysgenesis (ASD) and developmental glaucoma; congenital deafness and vestibular dysfunction
Center for Tumor Immunology Research
Program for Advanced Immune Bioimaging
Pharmacology & PhysiologyMicrobiology & Immunology
Research Interest:
Cancer immunotherapy/Host immune response to influenza infection/ Inflammation biology of sepsis
Research Interest: Cellular and molecular processes leading to scleroderma (fibrosis)
Urology
Research Interest: Extracellular vesicles (Evs), Exosomes, for their roles in cancer development, progression and response to treatment in Urology cancers.
Flaum Eye Institute
Ophthalmology
Research Interest: Neurobiology of glaucoma, molecular processes that lead to retinal ganglion cell death.
Research Interest:
Research in our laboratory focuses on materials design for tissue regeneration. Other areas of interest include microRNAs and the amelogenin extracellular matrix molecule.
Medicine
Environmental Medicine
Pediatrics
Research Interest:
Genetic and environmental susceptibility to developmental lung injury
Research Interest: Analysis of gene regulatory networks in cancer; role of immunogenetics in transplant
Microbiology & Immunology
Pathology & Laboratory Medicine
Research Interest:
Platelets in vascular injury and inflammation
Microbiology & Immunology
Research Interest:
Understanding host-pathogen interactions and the osteoimmunology of orthopaedic infections
Pediatrics
Research Interest: Cellular and Molecular events underlying the ontogeny of the hematopoietic system.
Research Interest: Molecular mechanisms of angiogenesis and vascular remodeling in physiological and pathological conditions.
Research Interest: Genetic mechanisms in acute myeloid leukemia and myelodysplastic syndrome with focus on the zinc finger oncoprotein EVI1
Research Interest:
Using primarily human pluripotent stem cell models, we examine astrocyte development in normal and pathological conditions, the role of astrocytes in modulating response to injury or stress, the role of altered RNA processing and translation in neural development, and the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy.
Research Interest: Juvenile Idiopathic arthritis. Imaging of lymph nodes as a martyr for arthritic flare in RA, lymphangiogenesis in Arthritic flare in murine model of erosive arthritis.
Pediatrics
Research Interest:
The mechanisms of lung vascular endothelial cell dysfunction in acute lung injury
Medicine
Public Health Sciences
Dentistry
Research Interest:
Redox signaling mechanism of Proinflammatory gene expression in pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants
Research Interest:
Innate cell antiviral responses, allergic inflammation, mucosal/airway immunity, vaccine responses
Urology
Medicine
Biomedical Engineering
Microbiology & Immunology
Orthopaedics
Research Interest: Inflammatory bone loss as seen in rheumatoid arthritis, infections, tumor metastasis and wear debris induced osteolysis around prosthetic implants
Biomedical Genetics
Ophthalmology
Research Interest:
Using patient-derived human induced pluripotent stem cells (hiPSCs) to study the molecular mechanism of specific retinal and neurological diseases and applying that knowledge to pharmacologically target certain retinal disorders in patient-derived cells.
Pharmacology & Physiology
Biomedical Engineering
Research Interest:
Cellular and molecular mechanisms of heart development, disease, and regeneration; Transcriptional regulation of fibroblast plasticity and cardiac fibrosis
Medicine
Research Interest:
Understanding how regulation of RNA Polymerase II activity regulates cellular differentiation, with a focus on erythropoiesis. Delineating epigenetic control of normal erythropoiesis; determining the contribution of disrupted epigenetic regulation to inherited anemias.
Research Interest:
Our research program focuses on mechanisms underlying gene environment interaction in pregnancy. We are interested in elucidating how environmental factors influence epigenetic regulation of developmental-relevant genes including imprinted genes, and how exposure modulates maternal-fetal health.
Flaum Eye Institute
Neuroscience
Pharmacology & Physiology
Research Interest:
Retinal degeneration and maladaptive plasticity in inner retinal circuits.
Program for Advanced Immune Bioimaging
Microbiology & ImmunologyResearch Interest: Systems approach utilizing bioinformatics, and dynamic modeling tools to study immune response to infections and vaccination.
Research Interest: Cancer epigenetics: the role of DNA methylation and chromatin in driving cancer phenotypes and as a target for therapeutic intervention
Pediatrics
Biomedical Engineering
Research Interest:
The Wilson ECLIPSe (Engineering & Clinical Laboratory for Innovation in Pediatric Surgery) lab addresses a wide array of topics that arise within the fields of biomedical engineering and clinical surgery, including studies that range from using computational techniques designed to support clinical decision-making to studies aimed at modeling both anatomic and functional characteristics of organ systems.
Environmental Medicine
Ophthalmology
Research Interest: Understanding the key molecular and cellular pathways involved in eye disease, with a particular focus on Thyroid Eye Disease (TED)
Microbiology & Immunology
Research Interest: Immune response and Pathogenesis of lung injury and related pulmonary inflammation
Research Interest: Identifying the molecular mechanisms by which genetic and epigenetic regulators modulate development, homeostasis and disease progression of musculoskeletal tissues, with a particular focus on cartilage and bone.
Research Interest: Regulation of bone cell function in inflammatory bone loss
Research Interest: Regulation and Function of Cyclic Nucleotide Phosphodiesterases in the Cardiovascular System
Mitochondrial Research and Innovation Group
Biochemistry & BiophysicsMedicine
Research Interest:
Pathophysiological function and molecular mechanism of new non-coding RNAs and RNA-binding proteins and translational control in cardiac system and cardiovascular disease
Dentistry
Pharmacology & Physiology
Research Interest:
NF-kB signaling pathway, Apoptosis signaling pathway, Bone metabolism, and Osteoimmunology.
George H. Whipple Laboratory for Cancer Research
UrologyPathology & Laboratory Medicine
Research Interest: Role of the estrogen receptor (ER) and androgen receptor (AR) in urological diseases, including prostate cancer, bladder cancer, benign prostatic hyperplasia (BPH) and male fertility.
Research Interest: Molecular mechanisms of skeletal repair in bone loss due to traumatic injury, tumor and bone graft.