Recent Publications
Recent Publications
- Microglia depletion leads to increased susceptibility to ocular hypertension-dependent glaucoma.; Frontiers in aging neuroscience; Vol 16, pp. 1396443. 2024 Jul 02.
- IL1A enhances TNF-induced retinal ganglion cell death.; bioRxiv : the preprint server for biology. 2024 Jun 01.
- Neuronal protein phosphatase 1β regulates glutamate release, cortical myelination, node of Ranvier formation, and action potential propagation in the optic nerve.; bioRxiv : the preprint server for biology. 2024 May 10.
- Microglia Depletion leads to Increased Susceptibility to Ocular Hypertension-Dependent Glaucoma.; bioRxiv : the preprint server for biology. 2024 Mar 10.
- BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps.; Molecular neurodegeneration; Vol 18(1), pp. 67. 2023 Sep 26.
- Age- and glaucoma-induced changes to the ocular glymphatic system.; Neurobiology of disease. 2023 Jan 11.
- TNF-α and NF-κB signaling play a critical role in cigarette smoke-induced epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy.; PloS one; Vol 17(9), pp. e0271950. 2022 Sep 01.
- BclXL (Bcl2l1) gene therapy lessens retinal ganglion cell soma loss but not axonal degeneration after acute axonal injury.; Cell death discovery; Vol 8(1), pp. 331. 2022 Jul 22.
- Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death.; Cell death discovery; Vol 8(1). 2022 Apr 16.
- Transcriptional control of retinal ganglion cell death after axonal injury.; Cell death & disease; Vol 13(3). 2022 Mar 16.
- Endothelin 1-induced retinal ganglion cell death is largely mediated by JUN activation.; Cell death & disease; Vol 11(9). 2020 Sep 26.
- A Mouse Model of Proliferative Vitreoretinopathy Induced by Intravitreal Injection of Gas and RPE Cells.; Translational vision science & technology; Vol 9(7). 2020 Jun.
- An ocular glymphatic clearance system removes β-amyloid from the rodent eye.; Science translational medicine; Vol 12(536). 2020 Mar 25.
- Salinomycin inhibits proliferative vitreoretinopathy formation in a mouse model.; PloS one; Vol 15(12). 2020.
- Gabor domain optical coherence microscopy combined with laser scanning confocal fluorescence microscopy.; Biomedical optics express; Vol 10(12). 2019 Dec 01.
- Axon injury signaling and compartmentalized injury response in glaucoma.; Progress in retinal and eye research. 2019 Jul 10.
- DDIT3 (CHOP) contributes to retinal ganglion cell somal loss but not axonal degeneration in DBA/2J mice.; Cell death discovery; Vol 5. 2019.
- The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology.; PloS one; Vol 14(9). 2019.
- Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice.; Cell death & disease; Vol 9(6). 2018 Jun 13.
- Assessment of intrinsic and extrinsic signaling pathway in excitotoxic retinal ganglion cell death.; Scientific reports; Vol 8(1). 2018 Mar 15.
- Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury.; Experimental eye research. 2018 Mar 08.
- Trabecular meshwork morphogenesis: A comparative analysis of wildtype and anterior segment dysgenesis mouse models.; Experimental eye research. 2018 Feb 13.
- Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death.; Cell death & disease; Vol 9(11). 2018 Jan 26.
- Ciliary margin-derived BMP4 does not have a major role in ocular development.; PloS one; Vol 13(5). 2018.
- Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury.; Molecular neurodegeneration; Vol 12(1). 2017 Oct 02.
- KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS.; The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017 Sep 04.
- JUN is important for ocular hypertension-induced retinal ganglion cell degeneration.; Cell death & disease; Vol 8(7). 2017 Jul 20.
- Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.; Proceedings of the National Academy of Sciences of the United States of America. 2017 Apr 26.
- G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling.; Cell reports; Vol 17(10). 2016 Dec 06.
- Novel axon projection after stress and degeneration in the Dscam mutant retina.; Molecular and cellular neurosciences; Vol 71. 2016 Mar.
- Neuroprotection for glaucoma: Requirements for clinical translation.; Experimental eye research; Vol 157, pp. 34-37. 2016 Jan 09.
- Col4a1 mutations cause progressive retinal neovascular defects and retinopathy.; Scientific reports; Vol 6. 2016.
- Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.; Experimental eye research; Vol 141. 2015 Dec.
- Quantitative measurement of retinal ganglion cell populations via histology-based random forest classification.; Experimental eye research. 2015 Oct 22.
- Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma in Col4a1 Mutant Mice.; Investigative ophthalmology & visual science; Vol 56(11). 2015 Oct.
- DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury.; Neurobiology of disease; Vol 69. 2014 Sep.
- Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival.; Journal of cell science; Vol 127(Pt 5). 2014 Mar 1.
- Focal damage to macaque photoreceptors produces persistent visual loss.; Experimental eye research; Vol 119. 2014 Feb.
- DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation.; PloS one; Vol 9(9). 2014.
- Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush.; Journal of neuroinflammation; Vol 11. 2014.
- Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice.; PloS one; Vol 9(4). 2014.
- Intrinsic axonal degeneration pathways are critical for glaucomatous damage.; Experimental neurology; Vol 246. 2013 Aug.
- JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells.; Experimental eye research; Vol 112. 2013 Jul.
- Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells.; The Journal of biological chemistry; Vol 288(25). 2013 Jun 21.
- Adding metabolomics to the toolbox for studying retinal disease.; Investigative ophthalmology & visual science; Vol 54(6). 2013 Jun.
- Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye.; Proceedings of the National Academy of Sciences of the United States of America; Vol 110(22). 2013 May 28.
- Deficiency in Bim, Bid and Bbc3 (Puma) do not prevent axonal injury induced death.; Cell death and differentiation; Vol 20(1). 2013 Jan.
- BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cells.; Molecular and cellular neurosciences; Vol 51(1-2). 2012 Aug.
- JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death.; Neurobiology of disease; Vol 46(2). 2012 May.
- Adaptive optics retinal imaging in the living mouse eye.; Biomedical optics express; Vol 3(4). 2012 Apr 1.
- Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma.; The Journal of clinical investigation; Vol 122(4). 2012 Apr.
- Mutations in a P-type ATPase gene cause axonal degeneration.; PLoS genetics; Vol 8(8). 2012.
- The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice.; Scientific reports; Vol 2. 2012.
- The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65.; Human molecular genetics; Vol 20(13). 2011 Jul 1.
- Ocular fibroblast diversity: implications for inflammation and ocular wound healing.; Investigative ophthalmology & visual science; Vol 52(7). 2011 Jun.
- Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.; The Journal of clinical investigation; Vol 121(4). 2011 Apr.
- Intravitreal injection of AAV2 transduces macaque inner retina.; Investigative ophthalmology & visual science; Vol 52(5). 2011 Apr.
- Optical properties of the mouse eye.; Biomedical optics express; Vol 2(4). 2011.
- BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina.; Molecular neurodegeneration; Vol 6. 2011.
- Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data.; BMC genomics; Vol 12. 2011.
- Endoplasmic reticulum stress as a primary pathogenic mechanism leading to age-related macular degeneration.; Advances in experimental medicine and biology; Vol 664. 2010.
- MATH5 controls the acquisition of multiple retinal cell fates.; Molecular brain; Vol 3. 2010.
- Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration.; American journal of physiology. Cell physiology; Vol 297(5). 2009 Nov.
- In-vivo imaging of retinal nerve fiber layer vasculature: imaging histology comparison.; BMC ophthalmology; Vol 9. 2009 Aug 23.
- BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 29(13). 2009 Apr 1.
- Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection.; Progress in brain research; Vol 173. 2008.
- Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma.; The Journal of cell biology; Vol 179(7). 2007 Dec 31.
- Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1.; BMC genetics; Vol 8. 2007.
- Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model.; BMC neuroscience; Vol 8. 2007.
- Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma.; BMC biology; Vol 4. 2006.
- Glaucoma: thinking in new ways-a rôle for autonomous axonal self-destruction and other compartmentalised processes?; Progress in retinal and eye research; Vol 24(6). 2005 Nov.
- Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice.; The Journal of cell biology; Vol 171(2). 2005 Oct 24.
- Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration.; Visual neuroscience; Vol 22(5). 2005 Sep.
- Myosin VI is required for normal retinal function.; Experimental eye research; Vol 81(1). 2005 Jul.
- Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage.; PLoS genetics; Vol 1(1). 2005 Jul.
- High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma.; Proceedings of the National Academy of Sciences of the United States of America; Vol 102(12). 2005 Mar 22.
- Complex genetics of glaucoma susceptibility.; Annual review of genomics and human genetics; Vol 6. 2005.
- Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes.; Journal of cell science; Vol 117(Pt 26). 2004 Dec 15.
- Myosin Va is required for normal photoreceptor synaptic activity.; Journal of cell science; Vol 117(Pt 19). 2004 Sep 1.
- Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration.; Experimental eye research; Vol 77(6). 2003 Dec.
- Modification of ocular defects in mouse developmental glaucoma models by tyrosinase.; Science (New York, N.Y.); Vol 299(5612). 2003 Mar 7.
- Loss of myosin VI reduces secretion and the size of the Golgi in fibroblasts from Snell's waltzer mice.; The EMBO journal; Vol 22(3). 2003 Feb 3.
- Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations.; Nature neuroscience; Vol 5(1). 2002 Jan.
- Electroretinographic anomalies in mice with mutations in Myo7a, the gene involved in human Usher syndrome type 1B.; Investigative ophthalmology & visual science; Vol 42(3). 2001 Mar.
- Laminin expression in adult and developing retinae: evidence of two novel CNS laminins.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 20(17). 2000 Sep 1.
- The roles of unconventional myosins in hearing and deafness.; Essays in biochemistry; Vol 35. 2000.
- Roles of the extracellular matrix in retinal development and maintenance.; Results and problems in cell differentiation; Vol 31. 2000.
- Disruption of laminin beta2 chain production causes alterations in morphology and function in the CNS.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 19(21). 1999 Nov 1.
- Identification of the cellular source of laminin beta2 in adult and developing vertebrate retinae.; The Journal of comparative neurology; Vol 389(4). 1997 Dec 29.
- Developmental expression of laminin beta 2 in rat retina. Further support for a role in rod morphogenesis.; Investigative ophthalmology & visual science; Vol 37(8). 1996 Jul.