Flaum Eye Institute / Research / Labs / Singh Lab / Publications

Recent Publications

1. Han J
2. Chear S
3. Talbot J
4. Swier V
5. Booth C
6. Reuben-Thomas C
7. Dalvi S
8. Weimer JM
9. Hewitt AW
10. Cook AL
11. Singh R
Genetic and Cellular Basis of Impaired Phagocytosis and Photoreceptor Degeneration in CLN3 Disease.; Investigative ophthalmology & visual science; Vol 65(13), pp. 23. 2024 Nov 04.
1. Dalvi S
2. Roll M
3. Chatterjee A
4. Kumar LK
5. Bhogavalli A
6. Foley N
7. Arduino C
8. Spencer W
9. Reuben-Thomas C
10. Ortolan D
11. Pébay A
12. Bharti K
13. Anand-Apte B
14. Singh R
Human iPSC-based disease modeling studies identify a common mechanistic defect and potential therapies for AMD and related macular dystrophies.; Developmental cell. 2024 Sep 26.
1. Grenell A
2. Singh C
3. Raju M
4. Wolk A
5. Dalvi S
6. Jang GF
7. Crabb JS
8. Hershberger CE
9. Manian KV
10. Hernandez K
11. Crabb JW
12. Singh R
13. Du J
14. Anand-Apte B
Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells.; Molecular metabolism. 2024 Jul 22.
1. Han J
2. Chear S
3. Talbot J
4. Swier V
5. Booth C
6. Reuben-Thomas C
7. Dalvi S
8. Weimer JM
9. Hewitt AW
10. Cook AL
11. Singh R
Genetic and cellular basis of impaired phagocytosis and photoreceptor degeneration in CLN3 disease.; bioRxiv : the preprint server for biology. 2024 Jun 13.
1. Swier VJ
2. White KA
3. Johnson TB
4. Wang X
5. Han J
6. Pearce DA
7. Singh R
8. Drack AV
9. Pfeifer W
10. Rogers CS
11. Brudvig JJ
12. Weimer JM
A novel porcine model of CLN3 Batten disease recapitulates clinical phenotypes.; Disease models & mechanisms. 2023 Jun 12.
1. Chatterjee A
2. Singh R
Extracellular vesicles: an emerging player in retinal homeostasis.; Frontiers in cell and developmental biology; Vol 11, pp. 1059141. 2023 Apr 25.
1. Dalvi S
2. Chatterjee A
3. Singh R
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering.; Cell stem cell; Vol 30(3), pp. 243-245. 2023 Mar 02.
1. Manian KV
2. Galloway CA
3. Dalvi S
4. Emanuel AA
5. Mereness JA
6. Black W
7. Winschel L
8. Soto C
9. Li Y
10. Song Y
11. DeMaria W
12. Kumar A
13. Slukvin I
14. Schwartz MP
15. Murphy WL
16. Anand-Apte B
17. Chung M
18. Benoit DSW
19. Singh R
3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration.; Cell stem cell; Vol 28(5). 2021 May 06.
1. Manian KV
2. Galloway CA
3. Dalvi S
4. Emanuel AA
5. Mereness JA
6. Black W
7. Winschel L
8. Soto C
9. Li Y
10. Song Y
11. DeMaria W
12. Kumar A
13. Slukvin I
14. Schwartz MP
15. Murphy WL
16. Anand-Apte B
17. Chung M
18. Benoit DSW
19. Singh R
3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration.; Cell stem cell. 2021 Mar 29.
1. Tang C
2. Han J
3. Dalvi S
4. Manian K
5. Winschel L
6. Volland S
7. Soto CA
8. Galloway CA
9. Spencer W
10. Roll M
11. Milliner C
12. Bonilha VL
13. Johnson TB
14. Latchney L
15. Weimer JM
16. Augustine EF
17. Mink JW
18. Gullapalli VK
19. Chung M
20. Williams DS
21. Singh R
A human model of Batten disease shows role of CLN3 in phagocytosis at the photoreceptor-RPE interface.; Communications biology; Vol 4(1). 2021 Feb 05.
1. Gamm DM
2. Clark E
3. Capowski EE
4. Singh R
The Role of FGF9 In The Production of Neural Retina And RPE In A Pluripotent Stem Cell Model of Early Human Retinal Development.; American journal of ophthalmology. 2019 May 10.
1. Dalvi S
2. Galloway CA
3. Winschel L
4. Hashim A
5. Soto C
6. Tang C
7. MacDonald LA
8. Singh R
Environmental stress impairs photoreceptor outer segment (POS) phagocytosis and degradation and induces autofluorescent material accumulation in hiPSC-RPE cells.; Cell death discovery; Vol 5. 2019.
1. Dalvi S
2. Galloway CA
3. Singh R
Pluripotent Stem Cells to Model Degenerative Retinal Diseases: The RPE Perspective.; Advances in experimental medicine and biology; Vol 1186. 2019.
1. Anand-Apte B
2. Chao JR
3. Singh R
4. Stöhr H
Sorsby fundus dystrophy: Insights from the past and looking to the future.; Journal of neuroscience research. 2018 Aug 21.
1. Galloway CA
2. Dalvi S
3. Shadforth AMA
4. Suzuki S
5. Wilson M
6. Kuai D
7. Hashim A
8. MacDonald LA
9. Gamm DM
10. Harkin DG
11. Singh R
Characterization of Human iPSC-RPE on a Prosthetic Bruch's Membrane Manufactured From Silk Fibroin.; Investigative ophthalmology & visual science; Vol 59(7). 2018 Jun 01.
1. Galloway CA
2. Dalvi S
3. Hung SSC
4. MacDonald LA
5. Latchney LR
6. Wong RCB
7. Guymer RH
8. Mackey DA
9. Williams DS
10. Chung MM
11. Gamm DM
12. Pébay A
13. Hewitt AW
14. Singh R
Drusen in patient-derived hiPSC-RPE models of macular dystrophies.; Proceedings of the National Academy of Sciences of the United States of America. 2017 Sep 06.
1. Singh R
2. Kuai D
3. Guziewicz KE
4. Meyer J
5. Wilson M
6. Lu J
7. Smith M
8. Clark E
9. Verhoeven A
10. Aguirre GD
11. Gamm DM
Pharmacological Modulation of Photoreceptor Outer Segment Degradation in a Human iPS Cell Model of Inherited Macular Degeneration.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 23(11). 2015 Nov.
1. Phillips MJ
2. Perez ET
3. Martin JM
4. Reshel ST
5. Wallace KA
6. Capowski EE
7. Singh R
8. Wright LS
9. Clark EM
10. Barney PM
11. Stewart R
12. Dickerson SJ
13. Miller MJ
14. Percin EF
15. Thomson JA
16. Gamm DM
Modeling human retinal development with patient-specific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2.; Stem cells (Dayton, Ohio); Vol 32(6). 2014 Jun.
1. Singh R
2. Phillips MJ
3. Kuai D
4. Meyer J
5. Martin JM
6. Smith MA
7. Perez ET
8. Shen W
9. Wallace KA
10. Capowski EE
11. Wright LS
12. Gamm DM
Functional analysis of serially expanded human iPS cell-derived RPE cultures.; Investigative ophthalmology & visual science; Vol 54(10). 2013 Oct.
1. McDowell TS
2. Wang ZY
3. Singh R
4. Bjorling D
CB1 cannabinoid receptor agonist prevents NGF-induced sensitization of TRPV1 in sensory neurons.; Neuroscience letters; Vol 551. 2013 Sep 13.
1. Gamm DM
2. Phillips MJ
3. Singh R
Modeling retinal degenerative diseases with human iPS-derived cells: current status and future implications.; Expert review of ophthalmology; Vol 8(3). 2013 Jun 1.
1. Singh R
2. Shen W
3. Kuai D
4. Martin JM
5. Guo X
6. Smith MA
7. Perez ET
8. Phillips MJ
9. Simonett JM
10. Wallace KA
11. Verhoeven AD
12. Capowski EE
13. Zhang X
14. Yin Y
15. Halbach PJ
16. Fishman GA
17. Wright LS
18. Pattnaik BR
19. Gamm DM
iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration.; Human molecular genetics; Vol 22(3). 2013 Feb 1.
1. Yamauchi D
2. Nakaya K
3. Raveendran NN
4. Harbidge DG
5. Singh R
6. Wangemann P
7. Marcus DC
Expression of epithelial calcium transport system in rat cochlea and vestibular labyrinth.; BMC physiology; Vol 10. 2010.
1. Wangemann P
2. Kim HM
3. Billings S
4. Nakaya K
5. Li X
6. Singh R
7. Sharlin DS
8. Forrest D
9. Marcus DC
10. Fong P
Developmental delays consistent with cochlear hypothyroidism contribute to failure to develop hearing in mice lacking Slc26a4/pendrin expression.; American journal of physiology. Renal physiology; Vol 297(5). 2009 Nov.
1. Singh R
2. Wangemann P
Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model.; American journal of physiology. Renal physiology; Vol 294(1). 2008 Jan.
1. Jabba SV
2. Oelke A
3. Singh R
4. Maganti RJ
5. Fleming S
6. Wall SM
7. Everett LA
8. Green ED
9. Wangemann P
Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model.; BMC medicine; Vol 4. 2006.
1. Singh R
2. Maganti RJ
3. Jabba SV
4. Wang M
5. Deng G
6. Heath JD
7. Kurn N
8. Wangemann P
Microarray-based comparison of three amplification methods for nanogram amounts of total RNA.; American journal of physiology. Cell physiology; Vol 288(5). 2005 May.