Recent Publications

• 1. Dalvi S
  2. Roll M
  3. Chatterjee A
  4. Kumar LK
  5. Bhogavalli A
  6. Foley N
  7. Arduino C
  8. Spencer W
  9. Reuben-Thomas C
  10. Ortolan D
  11. Pébay A
  12. Bharti K
  13. Anand-Apte B
  14. Singh R
  Human iPSC-based disease modeling studies identify a common mechanistic defect and potential therapies for AMD and related macular dystrophies.; Developmental cell. 2024 Sep 26.
• 1. Grenell A
  2. Singh C
  3. Raju M
  4. Wolk A
  5. Dalvi S
  6. Jang GF
  7. Crabb JS
  8. Hershberger CE
  9. Manian KV
  10. Hernandez K
  11. Crabb JW
  12. Singh R
  13. Du J
  14. Anand-Apte B
  Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells.; Molecular metabolism. 2024 Jul 22.
• 1. Han J
  2. Chear S
  3. Talbot J
  4. Swier V
  5. Booth C
  6. Reuben-Thomas C
  7. Dalvi S
  8. Weimer JM
  9. Hewitt AW
  10. Cook AL
  11. Singh R
  Genetic and cellular basis of impaired phagocytosis and photoreceptor degeneration in CLN3 disease.; bioRxiv : the preprint server for biology. 2024 Jun 13.
• 1. Swier VJ
  2. White KA
  3. Johnson TB
  4. Wang X
  5. Han J
  6. Pearce DA
  7. Singh R
  8. Drack AV
  9. Pfeifer W
  10. Rogers CS
  11. Brudvig JJ
  12. Weimer JM
  A novel porcine model of CLN3 Batten disease recapitulates clinical phenotypes.; Disease models & mechanisms. 2023 Jun 12.
• 1. Chatterjee A
  2. Singh R
  Extracellular vesicles: an emerging player in retinal homeostasis.; Frontiers in cell and developmental biology; Vol 11, pp. 1059141. 2023 Apr 25.
• 1. Dalvi S
  2. Chatterjee A
  3. Singh R
  AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering.; Cell stem cell; Vol 30(3), pp. 243-245. 2023 Mar 02.
• 1. Manian KV
  2. Galloway CA
  3. Dalvi S
  4. Emanuel AA
  5. Mereness JA
  6. Black W
  7. Winschel L
  8. Soto C
  9. Li Y
  10. Song Y
  11. DeMaria W
  12. Kumar A
  13. Slukvin I
  14. Schwartz MP
  15. Murphy WL
  16. Anand-Apte B
  17. Chung M
  18. Benoit DSW
  19. Singh R
  3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration.; Cell stem cell; Vol 28(5). 2021 May 06.
• 1. Manian KV
  2. Galloway CA
  3. Dalvi S
  4. Emanuel AA
  5. Mereness JA
  6. Black W
  7. Winschel L
  8. Soto C
  9. Li Y
  10. Song Y
  11. DeMaria W
  12. Kumar A
  13. Slukvin I
  14. Schwartz MP
  15. Murphy WL
  16. Anand-Apte B
  17. Chung M
  18. Benoit DSW
  19. Singh R
  3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration.; Cell stem cell. 2021 Mar 29.
• 1. Tang C
  2. Han J
  3. Dalvi S
  4. Manian K
  5. Winschel L
  6. Volland S
  7. Soto CA
  8. Galloway CA
  9. Spencer W
  10. Roll M
  11. Milliner C
  12. Bonilha VL
  13. Johnson TB
  14. Latchney L
  15. Weimer JM
  16. Augustine EF
  17. Mink JW
  18. Gullapalli VK
  19. Chung M
  20. Williams DS
  21. Singh R
  A human model of Batten disease shows role of CLN3 in phagocytosis at the photoreceptor-RPE interface.; Communications biology; Vol 4(1). 2021 Feb 05.
• 1. Gamm DM
  2. Clark E
  3. Capowski EE
  4. Singh R
  The Role of FGF9 In The Production of Neural Retina And RPE In A Pluripotent Stem Cell Model of Early Human Retinal Development.; American journal of ophthalmology. 2019 May 10.
• 1. Dalvi S
  2. Galloway CA
  3. Winschel L
  4. Hashim A
  5. Soto C
  6. Tang C
  7. MacDonald LA
  8. Singh R
  Environmental stress impairs photoreceptor outer segment (POS) phagocytosis and degradation and induces autofluorescent material accumulation in hiPSC-RPE cells.; Cell death discovery; Vol 5. 2019.
• 1. Dalvi S
  2. Galloway CA
  3. Singh R
  Pluripotent Stem Cells to Model Degenerative Retinal Diseases: The RPE Perspective.; Advances in experimental medicine and biology; Vol 1186. 2019.
• 1. Anand-Apte B
  2. Chao JR
  3. Singh R
  4. Stöhr H
  Sorsby fundus dystrophy: Insights from the past and looking to the future.; Journal of neuroscience research. 2018 Aug 21.
• 1. Galloway CA
  2. Dalvi S
  3. Shadforth AMA
  4. Suzuki S
  5. Wilson M
  6. Kuai D
  7. Hashim A
  8. MacDonald LA
  9. Gamm DM
  10. Harkin DG
  11. Singh R
  Characterization of Human iPSC-RPE on a Prosthetic Bruch's Membrane Manufactured From Silk Fibroin.; Investigative ophthalmology & visual science; Vol 59(7). 2018 Jun 01.
• 1. Galloway CA
  2. Dalvi S
  3. Hung SSC
  4. MacDonald LA
  5. Latchney LR
  6. Wong RCB
  7. Guymer RH
  8. Mackey DA
  9. Williams DS
  10. Chung MM
  11. Gamm DM
  12. Pébay A
  13. Hewitt AW
  14. Singh R
  Drusen in patient-derived hiPSC-RPE models of macular dystrophies.; Proceedings of the National Academy of Sciences of the United States of America. 2017 Sep 06.
• 1. Singh R
  2. Kuai D
  3. Guziewicz KE
  4. Meyer J
  5. Wilson M
  6. Lu J
  7. Smith M
  8. Clark E
  9. Verhoeven A
  10. Aguirre GD
  11. Gamm DM
  Pharmacological Modulation of Photoreceptor Outer Segment Degradation in a Human iPS Cell Model of Inherited Macular Degeneration.; Molecular therapy : the journal of the American Society of Gene Therapy; Vol 23(11). 2015 Nov.
• 1. Phillips MJ
  2. Perez ET
  3. Martin JM
  4. Reshel ST
  5. Wallace KA
  6. Capowski EE
  7. Singh R
  8. Wright LS
  9. Clark EM
  10. Barney PM
  11. Stewart R
  12. Dickerson SJ
  13. Miller MJ
  14. Percin EF
  15. Thomson JA
  16. Gamm DM
  Modeling human retinal development with patient-specific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2.; Stem cells (Dayton, Ohio); Vol 32(6). 2014 Jun.
• 1. Singh R
  2. Phillips MJ
  3. Kuai D
  4. Meyer J
  5. Martin JM
  6. Smith MA
  7. Perez ET
  8. Shen W
  9. Wallace KA
  10. Capowski EE
  11. Wright LS
  12. Gamm DM
  Functional analysis of serially expanded human iPS cell-derived RPE cultures.; Investigative ophthalmology & visual science; Vol 54(10). 2013 Oct.
• 1. McDowell TS
  2. Wang ZY
  3. Singh R
  4. Bjorling D
  CB1 cannabinoid receptor agonist prevents NGF-induced sensitization of TRPV1 in sensory neurons.; Neuroscience letters; Vol 551. 2013 Sep 13.
• 1. Gamm DM
  2. Phillips MJ
  3. Singh R
  Modeling retinal degenerative diseases with human iPS-derived cells: current status and future implications.; Expert review of ophthalmology; Vol 8(3). 2013 Jun 1.
• 1. Singh R
  2. Shen W
  3. Kuai D
  4. Martin JM
  5. Guo X
  6. Smith MA
  7. Perez ET
  8. Phillips MJ
  9. Simonett JM
  10. Wallace KA
  11. Verhoeven AD
  12. Capowski EE
  13. Zhang X
  14. Yin Y
  15. Halbach PJ
  16. Fishman GA
  17. Wright LS
  18. Pattnaik BR
  19. Gamm DM
  iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration.; Human molecular genetics; Vol 22(3). 2013 Feb 1.
• 1. Yamauchi D
  2. Nakaya K
  3. Raveendran NN
  4. Harbidge DG
  5. Singh R
  6. Wangemann P
  7. Marcus DC
  Expression of epithelial calcium transport system in rat cochlea and vestibular labyrinth.; BMC physiology; Vol 10. 2010.
• 1. Wangemann P
  2. Kim HM
  3. Billings S
  4. Nakaya K
  5. Li X
  6. Singh R
  7. Sharlin DS
  8. Forrest D
  9. Marcus DC
  10. Fong P
  Developmental delays consistent with cochlear hypothyroidism contribute to failure to develop hearing in mice lacking Slc26a4/pendrin expression.; American journal of physiology. Renal physiology; Vol 297(5). 2009 Nov.
• 1. Singh R
  2. Wangemann P
  Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model.; American journal of physiology. Renal physiology; Vol 294(1). 2008 Jan.
• 1. Jabba SV
  2. Oelke A
  3. Singh R
  4. Maganti RJ
  5. Fleming S
  6. Wall SM
  7. Everett LA
  8. Green ED
  9. Wangemann P
  Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model.; BMC medicine; Vol 4. 2006.
• 1. Singh R
  2. Maganti RJ
  3. Jabba SV
  4. Wang M
  5. Deng G
  6. Heath JD
  7. Kurn N
  8. Wangemann P
  Microarray-based comparison of three amplification methods for nanogram amounts of total RNA.; American journal of physiology. Cell physiology; Vol 288(5). 2005 May.