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URMC / Labs / Uddin Lab / Current Research Projects

 

Current Research Projects

Project 1:  Advanced MRI in the Co-occurrence of Liver Disease and HIV Infection

Liver-related concerns persist among people living with HIV (PLWH), despite antiretroviral therapy benefits. Non-alcoholic fatty liver disease (NAFLD) affects up to 50% of those with HIV, influenced by the virus and treatment. 

Learn more about Advanced MRI in the Co-occurrence of Liver Disease and HIV Infection

Project 2:  Automated machine learning-based brain artery segmentation, and feature extraction on MR Angiography

Cerebrovascular disease is a global health concern, impacting mortality and well-being. Time-of-flight magnetic resonance angiography (TOF-MRA) is a common noninvasive method to assess vascular abnormalities. 

Learn more about Automated machine learning-based brain artery segmentation, and feature extraction on MR Angiography

Project 3:  Development of a robust technique for estimating extracellular free water and neurite density from single-shell diffusion MRI data

The extracellular free water (FW) signal fraction, indicating the relative amount of freely diffusing water in the extracellular space, can unveil neuroaxonal damage impacting tissue diffusion characteristics.

Learn more about Development of a robust technique for estimating extracellular free water and neurite density from single-shell diffusion MRI data

Project 4:  Tensor-valued diffusion MRI for neuronal injury in people living with HIV

Globally, 38 million individuals are affected by HIV. While combination antiretroviral treatment (cART) has made HIV manageable, eliminating the virus from the brain remains challenging. Traditional methods for assessing neuroinflammation are invasive or involve radiation, lacking MRI's exceptional spatial resolution. 

Learn more about Tensor-valued diffusion MRI for neuronal injury in people living with HIV

Project 5:  Mapping changes in iron distribution and myelin integrity in multiple sclerosis

Multiple sclerosis (MS) is a debilitating disorder characterized by inflammation, demyelination, and neuroaxonal loss within the central nervous system. This condition is often associated with changes in the distribution of iron. 

Learn more about Mapping changes in iron distribution and myelin integrity in multiple sclerosis