Faculty
Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.
Toxicology of inhaled particulate matter on the lung, cardiovascular, and central nervous systems
Understanding the pathogenesis of Acute Lung Injury (ALI), a life threatening pulmonary inflammatory condition
Defining molecular pathways by which allergens and particulates activate epithelia and dendritic cells in the lung immune system
Pneumocystis carinii pneumonia; Infections in the immunocompromised host
Understanding the mechanisms by which the extracellular matrix protein, fibronectin, affects cell and tissue functions that are critical for wound repair. We study both the structural mechanisms and intracellular signaling events that mediate cell and tissue responses to matrix fibronectin. In turn, we are using this information to develop novel technologies for tissue engineering, and therapeutic approaches to promote tissue regeneration in chronic wounds.
Development of the infant microbiome and immune system, and how that relates to development of allergic diseases
Cellular and molecular mechanisms of lung fibrosis; new treatments for interstitial lung diseases
Delineating mechanisms by which environmental exposures during different life stages alter immune function
Genetic and environmental susceptibility to developmental lung injury
Airway epithelial stem cells in chemical inhalation exposures
Defining how an aberrant oxygen environment and oxygen-induced DNA damage signaling alter distal lung development, the host response to respiratory viral infections, and promotes cardiovascular disease later in life
Team approaches to patient-centered, clinical and translational investigation in sepsis and critical illness
Chronic lung disease of prematurity and lung development
The mechanisms of lung vascular endothelial cell dysfunction in acute lung injury
Redox signaling mechanism of Proinflammatory gene expression in pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants
Neonatal immunology; T cell function in preterm infants
Immune responses to respiratory viruses and experimental vaccines
Thrombosis and platelet activation in vascular pathology of pulmonary hypertension; clinical trial design in pulmonary hypertension
