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Research Interest: Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.
Research Interest: Effects of strain on pulmonary epithelium
Research Interest: Wnt signaling in cardiovascular development
Research Interest: Immunizations and infections in the premature infant
Research Interest: Molecular mechanisms of gene delivery and development of gene therapies for lung disease
Research Interest: Prematurity and lung disease
Research Interest: Toxicology of inhaled ultrafine particles (UFPs) on the lung, cardiovascular and central nervous system
Research Interest: Understanding the pathogenesis of Acute Lung Injury (ALI), a life threatening pulmonary inflammatory condition
Research Interest: Delineating the role of alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli, including oxidant induced signaling in the pulmonary epithelium and macrophages, and epithelial production of mediators that regulate inflammatory functions of macrophages.
Research Interest: Defining molecular pathways by which allergens and particulates activate epithelia and dendritic cells in the lung immune system
Research Interest: Pneumocystis carinii pneumonia; Infections in the immunocompromised host
Research Interest: Understanding the mechanisms by which the extracellular matrix protein, fibronectin, affects cell and tissue functions that are critical for wound repair. We study both the structural mechanisms and intracellular signaling events that mediate cell and tissue responses to matrix fibronectin. In turn, we are using this information to develop novel technologies for tissue engineering, and therapeutic approaches to promote tissue regeneration in chronic wounds.
Research Interest: Development of the infant microbiome and immune system, and how that relates to development of allergic diseases
Research Interest: Investigating how novel receptor-based therapeutics modify cytokine production to mitigate lung injury and fibrosis
Research Interest: Delineating mechanisms by which environmental exposures during different life stages alter immune function
Research Interest: Investigating factors that both increase and decrease the risk of developing asthma, wheezing, and allergic disorders in childhood
Research Interest: Determining the therapeutic promise of engineered tRNAs for treatment of nonsense associated diseases and investigating the pathomechanisms of skeletal muscle weakness and wasting in myotonic dystrophy
Research Interest: Genetic and environmental susceptibility to developmental lung injury
Research Interest: Airway epithelial stem cells in chemical inhalation exposures
Research Interest: Understanding mechanisms of pathology in common inflammatory conditions of children
Research Interest: Defining how an aberrant oxygen environment and oxygen-induced DNA damage signaling alter distal lung development, the host response to respiratory viral infections, and promotes cardiovascular disease later in life
Research Interest: Biokinetics, Effects and Mechanisms of Inhaled Micro- and Nano- Particles: Dosimetry, Risk Extrapolation and Risk Assessment
Research Interest: Team approaches to patient-centered, clinical and translational investigation in sepsis and critical illness
Research Interest: Chronic lung disease of prematurity and lung development
Research Interest: Juvenile Idiopathic arthritis. Imaging of lymph nodes as a martyr for arthritic flare in RA, lymphangiogenesis in Arthritic flare in murine model of erosive arthritis.
Research Interest: The mechanisms of lung vascular endothelial cell dysfunction in acute lung injury
Research Interest: Redox signaling mechanism of Proinflammatory gene expression in pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants
Research Interest: Neonatal immunology; T cell function in preterm infants
Research Interest:
Immune responses to respiratory viruses and experimental vaccines
Research Interest: Thrombosis and platelet activation in vascular pathology of pulmonary hypertension; clinical trial design in pulmonary hypertension
Research Interest: Discovering the effects of high (therapeutic) and low (environmentally-relevant) doses of radiation and their interactions with other toxic elements, such as commonly encountered infections, and better understanding differential effects of radiation in adults versus children.
Research Interest: Immune response and Pathogenesis of lung injury and related pulmonary inflammation
