Faculty
Primary Faculty
Pharmacology & Physiology Research Interest: TRP channels, Ca2+ signaling, blood vessels, nanoscale signaling complexes, cerebral vascular function, neurovascular coupling, autoregulation, cerebral small vessel diseases, vascular dementia
Understanding the molecular basis of behaviors relevant to stress and the actions of fast antidepressant and anxiolytic drugs, aiming to identify specific circuits, neuronal subpopulations and synaptic mechanisms involved in these responses.
Basal ganglia and degenerative diseases
Understanding the mechanisms by which the extracellular matrix protein, fibronectin, affects cell and tissue functions that are critical for wound repair. We study both the structural mechanisms and intracellular signaling events that mediate cell and tissue responses to matrix fibronectin. In turn, we are using this information to develop novel technologies for tissue engineering, and therapeutic approaches to promote tissue regeneration in chronic wounds.
Mechanotransduction of musculoskeletal cells and associated human disease; Physiology and pathophysiology of mechanosensitive ion channels
Mechanisms of neurotransmitter receptor function
Elucidate the molecular mechanisms of divalent metal neurotoxicity and mitochondrial dysfunction in Alzheimer's disease pathogenesis
Director, Center for Advanced Light Microscopy and Nanoscopy
Molecular and signaling mechanisms of synaptic plasticity in memory formation and mental health
Research Faculty
Purinergic signaling in peripheral nociceptive nerve, neurovascular coupling, stroke injury and astrocytic communication
Secondary Faculty
Signaling transduction mechanisms in the vascular system
The role of CAv 1, 2 in tendon formation and heterotopic bone (HO) formation
Our research interests span three areas including epigenetic mechanisms of mitotic cell division, chromatin, heterochromatin, histone variants and modifications; biomineralization of odontogenic tissues and finally generating tools for engineering and regeneration of complex periodontal tissues.
Medicine Pharmacology & Physiology Research Interest: Understanding the neural pathways and biochemical processes involved in controlling blood pressure, hypertension, diabetes, and metabolic disorders
Role of Mitochondria in regulation of cell fate in normal stem cells and cancer cells
Translational women’s health research; To identify previously unknown mechanisms of disease for disabling vulvar conditions, namely vulvodynia and lichens
Understanding the pathogenesis of Acute Lung Injury (ALI), a life threatening pulmonary inflammatory condition
Understanding the roles of antioxidants in disease
Cancer immunotherapy/Host immune response to influenza infection/ Inflammation biology of sepsis
Investigation of the molecules, receptors, and neural circuits that influence social interactions, including the actions of mammalian pheromones
Structural and functional investigation of the molecular mechanisms, dynamics, cellular organization, and spatiotemporal aspects of G protein and cyclase signaling pathways. Cryo-EM; GPCRs; membrane proteins; signal transduction.
The mechanisms of lung vascular endothelial cell dysfunction in acute lung injury
Vascular Effects of Alcohol-role of Notch
Cellular and molecular mechanisms of heart development, disease, and regeneration; Transcriptional regulation of fibroblast plasticity and cardiac fibrosis
Retinal degeneration and maladaptive plasticity in inner retinal circuits.
Thrombosis and platelet activation in vascular pathology of pulmonary hypertension; clinical trial design in pulmonary hypertension
NF-kB signaling pathway, Apoptosis signaling pathway, Bone metabolism, and Osteoimmunology.
Developing intravital imaging-based approaches to better understand the bone marrow microenvironment regulating the skeletal, hematopoietic, and malignant stem cells
Emeritus Faculty
Metabolism and toxicity of halogen- and sulfur-containing chemicals and on the design and synthesis of mitochondrially targeted drugs
