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Research Interest: Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.
Research Interest: LncRNA control of heart development and disease; Discovery and function of micropeptides encoded by putative lncRNAs; Genome-editing by RNA-guided nucleases.
Research Interest: Pharmacology of brain and lymphocytic opioid receptors
Research Interest: Regulation of pre-mRNA splicing and polyadenylation in healthy and diseased states; the contribution of RNA processing to cancer biology; effects of small molecule drugs on RNA processing and gene expression.
Research Interest: Bioinorganic and Biophysical Chemistry of Metalloproteins
Research Interest: Cardioprotection against ischemia-reperfusion (IR) injury. Role of Mitochondria and metabolism in ischemic preconditioning and anesthetic preconditioning.
Research Interest: Understanding the interaction of HIV with glial cells; Developing an improved live attenuated influenza vaccine (LAIV); Elucidating the host cell response to infection by viral pathogens (with emphasis on SARS-CoV-2 and Adeno-associated virus, AAV)
Research Interest: Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Research Interest: Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.
Research Interest: Molecular mechanisms of prion propagation and pathogenesis
Research Interest: Microbial pathogens and the impact of human microbial flora on human health and disease.
Research Interest: Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.
Research Interest: Investigating membranes and membrane proteins via computer simulation
Research Interest: Regulation of transcription, nuclear processes, related to chromatin structure and function
Research Interest: Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Research Interest: Cancer immunotherapy/Host immune response to influenza infection/ Inflammation biology of sepsis
Research Interest: Biomimetic nanoparticles, super-resolution microscopy, and bio-inspired photocatalysis
Research Interest: Satellite DNA (repetitive DNA typically found at centromeres and telomeres), Meiotic Drive, and Selfish DNA using genomic, population genetic, molecular and cytological methods.
Research Interest: Determining the therapeutic promise of engineered tRNAs for treatment of nonsense associated diseases and investigating the pathomechanisms of skeletal muscle weakness and wasting in myotonic dystrophy
Research Interest: Mechanisms of neurotransmitter receptor function
Research Interest: RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Research Interest: Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.
Research Interest: Bacterial stress response; 3D Printing of Bacteria; Biomaterials
Research Interest: Carbohydrate and protein recognition, molecular design, and biomolecular sensing
Research Interest: Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Research Interest: The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.
Research Interest: Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Research Interest: Defining how an aberrant oxygen environment and oxygen-induced DNA damage signaling alter distal lung development, the host response to respiratory viral infections, and promotes cardiovascular disease later in life
Research Interest: The role of metabolism in lineage differentiation
Research Interest: Cellular and molecular mechanisms of heart development, disease, and regeneration; Transcriptional regulation of fibroblast plasticity and cardiac fibrosis
Research Interest: Understanding how regulation of RNA Polymerase II activity regulates cellular differentiation, with a focus on erythropoiesis. Delineating epigenetic control of normal erythropoiesis; determining the contribution of disrupted epigenetic regulation to inherited anemias.
Research Interest: Myotonic dystrophy, repeat expansion diseases, and therapeutic development for neuromuscular disorders.
Research Interest: Cancer epigenetics: the role of DNA methylation and chromatin in driving cancer phenotypes and as a target for therapeutic intervention
Research Interest: Mechanism and physiological importance of alternative polyadenylation; Integrator Complex and transcriptional control, development and application of next-generation sequencing technologies
Research Interest: Structure and function analysis of gene regulation by non-protein-coding (nc)RNAs as a basis for therapeutic development.
Research Interest: Optogenetics to study the roles of Reactive Oxygen Species (ROS) in mitochondrial physiology and stress signaling.
Research Interest: Pathophysiological function and molecular mechanism of new non-coding RNAs and RNA-binding proteins and translational control in cardiac system and cardiovascular disease
Research Interest: RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.
