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Research Interest: Defining the impact of environmental chemicals (e.g., metals and air pollution) on brain development and behavior, with emphasis on attributable risk to neurodevelopmental disorders.
Research Interest: Environmental epidemiology of the effect of air polution on respiratory health
Research Interest: Understanding the toxicological and biochemical properties of nanomaterial interactions with skin and the immune system; develop in vivo models to investigate nanoparticle skin penetration mechanisms, and develop novel biosensors to improve transdermal drug delivery and tissue engineering approaches.
Research Interest: Toxicology of inhaled ultrafine particles (UFPs) on the lung, cardiovascular and central nervous system
Research Interest: Delineating the role of alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli, including oxidant induced signaling in the pulmonary epithelium and macrophages, and epithelial production of mediators that regulate inflammatory functions of macrophages.
Research Interest: Nucleic acid modification and repair mechanisms linked to neurodevelopmental disorders, mitochondrial diseases, and cancer.
Research Interest: Defining molecular pathways by which allergens and particulates activate epithelia and dendritic cells in the lung immune system
Research Interest: Asthma and Improving quality of care
Research Interest: Early origins research, linking in utero environment to later life health and educational attainment
Research Interest: Multivariate statistical methods for data analysis; Chemical characterization of ambient aerosol samples; Emissions and properties of solid biomass combustion systems; Characterization of source/receptor relationships for ambient air pollutants; Experimental studies of homogeneous, heterogeneous, and ion-induced nucleation; Indoor air quality; Exposure and risk assessment.
Research Interest: Environmental and Maternal and Child Health Epidemiology: Defining the impact of environmental chemicals on immunity and immune-mediated diseases and as a mechanism for susceptibility to other disease outcomes, such as neurobehavioral disorders.
Research Interest: Development of the infant microbiome and immune system, and how that relates to development of allergic diseases
Research Interest: Community outreach and engagement, role of science in public decision-making
Research Interest: Delineating mechanisms by which environmental exposures during different life stages alter immune function
Research Interest: Investigating factors that both increase and decrease the risk of developing asthma, wheezing, and allergic disorders in childhood
Research Interest: Finding hidden groups and their meanings; latent variable modeling; methods and techniques for Bayesian solutions.
Research Interest: Glia-neuron interactions during synaptic plasticity in health and disease
Research Interest: Genetic and environmental susceptibility to developmental lung injury
Research Interest: Developing and coordinating a wide variety of science education and outreach programs for students (elementary through high school), teachers, and the general community.
Research Interest: Identification of different stem and precursor cell pools in CNS that may be critical for cell replacement therapies or are targets of insults that lead to developmental pathologies.
Research Interest: Developing methods to estimate gene regulatory networks from gene perturbation experiments
Research Interest: In vitro models of human lung and vascular barriers during inflammation
Research Interest: Airway epithelial stem cells in chemical inhalation exposures
Research Interest: Smoking Cessation in special populations, Technology/Web Assisted Risk Behavior Intervention and Dissemination of effective interventions to physician practices
Research Interest: The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.
Research Interest: Defining neuro-inflammatory processes that contribute to pathology and disease progression in Alzheimer's disease, as well as late CNS effects following radiation exposure
Research Interest: The mechanisms by which early stress exposures, including prenatal maternal anxiety and caregiving stress, may persistently shape children's behavioral and biological health
Research Interest: Defining how an aberrant oxygen environment and oxygen-induced DNA damage signaling alter distal lung development, the host response to respiratory viral infections, and promotes cardiovascular disease later in life
Research Interest: Biokinetics, Effects and Mechanisms of Inhaled Micro- and Nano- Particles: Dosimetry, Risk Extrapolation and Risk Assessment
Research Interest: Elucidate the molecular mechanisms of divalent metal neurotoxicity and mitochondrial dysfunction in Alzheimer's disease pathogenesis
Research Interest: Behavioral medicine and outcomes management include tobacco use and smoking interventions, obesity prevention and exercise
Research Interest: Identify new targets susceptible to environmental perturbation in relevance with neurodevelopment or neurodegenerative diseases by utilizing functional genetics/genomics (RNAi and CRISPR screens and Next-Generation sequencing), and molecular benchwork. Discover the link between genetic polymorphism of the targets and neurological diseases. Explore novel roles of extracellular vesicles (EV) in receptor signaling and cell communication. Identify EV-encapsulated biomolecules released by the placenta in response to environmental perturbation. Explore the roles of placenta-derived EVs on neurodevelopment or neurodegeneration
Research Interest: Chronic lung disease of prematurity and lung development
Research Interest: Redox signaling mechanism of Proinflammatory gene expression in pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants
Research Interest: Mechanisms of toxicity of the environmental contaminant and neurotoxicant methylmercury (MeHg), defining MeHg effects on early life development of neural and muscular systems at the molecular, cellular, and organismal levels using invertebrate and mammalian models, and detailed characterization of MeHg metabolism and elimination kinetics in humans.
Research Interest: Cardiovascular, respiratory, and perinatal/reproductive health effects of exposure to environmental agents, including ambient air pollution
Research Interest: Experimental platform using the amphibian Xenopus for research in immunotoxicology, fundamental and medical immunology
Research Interest: Develop a research program concentrating on identifying genetic modifiers of environmental factors in disease etiology using a combination of Drosophila genetics, cell culture, and rodent models
Research Interest: Neonatal immunology; T cell function in preterm infants
Research Interest: Neurotoxicology, Etiology of neurobehavioral disease, Endocrine dysfunction, Synergistic Toxicity.
Research Interest: Our research program focuses on mechanisms underlying gene environment interaction in pregnancy. We are interested in elucidating how environmental factors influence epigenetic regulation of developmental-relevant genes including imprinted genes, and how exposure modulates maternal-fetal health.
Research Interest: Using statistics in environmental health, measurement error, multiple outcomes, Bayesian inference
Research Interest: Understanding the key molecular and cellular pathways involved in eye disease, with a particular focus on Thyroid Eye Disease (TED)
Research Interest: Vascular Biology and Inflammation in Hypertension and Kidney Disease
Research Interest: Environmental and Neurologic Epidemiology: Defining influences of environmental exposures, in particular toxic metals, on cognitive outcomes in children and adults.
Thomas Clarkson, PhD
Philip Davidson, PhD
Mark Frampton, MD
Thomas Gasiewicz, PhD
Gary Myers, PhD
David Oakes, PhD
Mark Utell, MD
